Inflammasomes As Mediators of Immunity Against Influenza Virus

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2010 Dec 15

PMID 21147034

Citations 81

Authors

Iris K Pang

Akiko Iwasaki

Affiliations

Soon will be listed here.

Abstract

Influenza viruses infect a wide range of avian and mammalian host species including humans. Influenza viruses are a major cause of human respiratory infections and mortality. The innate immune system recognizes influenza viruses through multiple mechanisms. These include endosomal recognition through the Toll-like receptor 7 (TLR7) and cytosolic recognition through the retinoic acid inducible gene I (RIG-I). Recent studies also identified the role of nucleotide binding oligomerization domain (NOD)-like receptors (NLRs) in innate detection of influenza viruses, leading to the activation of the inflammasomes. Here, we review the cellular and molecular mechanisms by which influenza virus infection leads to inflammasome activation, and discuss the consequences of such activation in innate and adaptive immune defense against influenza viruses.

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