Three's Company: the Fission Yeast Actin Cytoskeleton

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2010 Dec 15

PMID 21145239

Citations 65

Authors

David R Kovar

Vladimir Sirotkin

Matthew Lord

Affiliations

Soon will be listed here.

Abstract

How the actin cytoskeleton assembles into different structures to drive diverse cellular processes is a fundamental cell biological question. In addition to orchestrating the appropriate combination of regulators and actin-binding proteins, different actin-based structures must insulate themselves from one another to maintain specificity within a crowded cytoplasm. Actin specification is particularly challenging in complex eukaryotes where a multitude of protein isoforms and actin structures operate within the same cell. Fission yeast Schizosaccharomyces pombe possesses a single actin isoform that functions in three distinct structures throughout the cell cycle. In this review we explore recent studies in fission yeast that help unravel how different actin structures operate in cells.

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