Tension Management in the Kinetochore

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 2010 Dec 15

PMID 21145023

Citations 15

Authors

Kerry Bloom

Elaine Yeh

Affiliations

Soon will be listed here.

Abstract

The kinetochore is the protein machine built at the centromere that integrates mechanical force and chemical energy from dynamic microtubules into directed chromosome motion. The kinetochore also provides a powerful signaling function that is able to alter the properties of the spindle checkpoint and initiate a signal transduction cascade that leads to inhibition of the anaphase promoting complex and cell cycle arrest. Together, the kinetochore accomplishes the feat of chromosome segregation with unparalleled accuracy. Errors in segregation lead to Down's syndrome, the most frequent inherited birth defect, pregnancy loss, and cancer. Over a century after the discovery of the kinetochore, an architectural map comprising greater than 100 proteins is emerging. Understanding the architecture and physical biology of the key components provides new insights into how this fascinating machine moves genomes.

Citing Articles

Different relative scalings between transient forces and thermal fluctuations tune regimes of chromatin organization.

Coletti A, Newhall K, Walker B, Bloom K ArXiv. 2024; .

PMID: 38979491 PMC: 11230345.

Physiological relevance of post-translational regulation of the spindle assembly checkpoint protein BubR1.

Bloom C, North B Cell Biosci. 2021; 11(1):76.

PMID: 33892776 PMC: 8066494. DOI: 10.1186/s13578-021-00589-2.

Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling.

Hsu J, Leu W, Hsu L, Ho C, Liu S, Guh J Front Oncol. 2020; 10:1274.

PMID: 32850387 PMC: 7427565. DOI: 10.3389/fonc.2020.01274.

A common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint.

Benzi G, Camasses A, Atsunori Y, Katou Y, Shirahige K, Piatti S EMBO Rep. 2020; 21(6):e50257.

PMID: 32307893 PMC: 7271318. DOI: 10.15252/embr.202050257.

The regulation of chromosome segregation via centromere loops.

Lawrimore J, Bloom K Crit Rev Biochem Mol Biol. 2019; 54(4):352-370.

PMID: 31573359 PMC: 6856439. DOI: 10.1080/10409238.2019.1670130.

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