Lobophytones O-T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum Pauciflorum

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2010 Dec 9

PMID 21139847

Citations 11

Authors

Pengcheng Yan

Zhiwei Deng

Leen van Ofwegen

Peter Proksch

Wenhan Lin

Affiliations

Soon will be listed here.

Abstract

Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O-S (1-5) and a new "monomeric" cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.

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