Ftz-f1 and Hr39 Opposing Roles on EcR Expression During Drosophila Mushroom Body Neuron Remodeling

Overview

Journal Nat Neurosci

Date 2010 Dec 7

PMID 21131955

Citations 43

Authors

Ana Boulanger

Christelle Clouet-Redt

Morgane Farge

Adrien Flandre

Thomas Guignard

Celine Fernando

Francois Juge

Jean-Maurice Dura

Affiliations

Soon will be listed here.

Abstract

Developmental axon pruning is a general mechanism that is required for maturation of neural circuits. During Drosophila metamorphosis, the larval-specific dendrites and axons of early γ neurons of the mushroom bodies are pruned and replaced by adult-specific processes. We found that the nuclear receptor ftz-f1 is required for this pruning, activates expression of the steroid hormone receptor EcR-B1, whose activity is essential for γ remodeling, and represses expression of Hr39, an ftz-f1 homologous gene. If inappropriately expressed in the γ neurons, HR39 inhibits normal pruning, probably by competing with endogenous FTZ-F1, which results in decreased EcR-B1 expression. EcR-B1 was previously identified as a target of the TGFβ signaling pathway. We found that the ftz-f1 and Hr39 pathway apparently acts independently of TGFβ signaling, suggesting that EcR-B1 is the target of two parallel molecular pathways that act during γ neuron remodeling.

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