A Tale of Tailless

Overview

Journal Dev Neurosci

Specialty Neurology

Date 2010 Dec 3

PMID 21124006

Citations 19

Authors

Hongxing Gui

Mei-Ling Li

Chih-Cheng Tsai

Affiliations

Soon will be listed here.

Abstract

Drosophila Tailless(Tll) and its vertebrate homologue Tlx are conserved orphan nuclear receptors specifically expressed in the eye and the forebrain. Tll and Tlx act primarily as transcriptional repressors through their interactions with transcriptional corepressors, Atrophin family proteins, and histone-tail/chromatin-modifying factors such as lysine-specific histone demethylase 1 and histone deacetylases. The functional importance of Tll and Tlx is made apparent by the recent discovery that they are expressed in neural stem cells (NSCs) and are required for self-renewal of these cells in both Drosophila and the mouse. This review provides a snapshot of current knowledge about Tll and Tlx and their transcriptional network, which maintains NSCs in developing and adult animals.

Citing Articles

Global repression by tailless during segmentation.

Masuda L, Sabino A, Reinitz J, Ramos A, Machado-Lima A, Andrioli L Dev Biol. 2023; 505:11-23.

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TLX, an Orphan Nuclear Receptor With Emerging Roles in Physiology and Disease.

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Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells.

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A role for the orphan nuclear receptor TLX in the interaction between neural precursor cells and microglia.

Kozareva D, Moloney G, Hoban A, Rossini V, Nally K, Cryan J Neuronal Signal. 2020; 3(1):NS20180177.

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CONSERVED AND EXAPTED FUNCTIONS OF NUCLEAR RECEPTORS IN ANIMAL DEVELOPMENT.

Bodofsky S, Koitz F, Wightman B Nucl Receptor Res. 2018; 4.

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References

Shi Y, Lie D, Taupin P, Nakashima K, Ray J, Yu R . Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature. 2004; 427(6969):78-83. DOI: 10.1038/nature02211. View

Betschinger J, Mechtler K, Knoblich J . Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell. 2006; 124(6):1241-53. DOI: 10.1016/j.cell.2006.01.038. View

Groszer M, Erickson R, Lesche R, Trumpp A, Zack J, Kornblum H . Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science. 2001; 294(5549):2186-9. DOI: 10.1126/science.1065518. View

Jimenez G, Guichet A, Ephrussi A, Casanova J . Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning. Genes Dev. 2000; 14(2):224-31. PMC: 316342. View

Corbin J, Gaiano N, Machold R, Langston A, Fishell G . The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. Development. 2000; 127(23):5007-20. DOI: 10.1242/dev.127.23.5007. View

Takahashi T, Nowakowski R, Caviness Jr V . Early ontogeny of the secondary proliferative population of the embryonic murine cerebral wall. J Neurosci. 1995; 15(9):6058-68. PMC: 6577693. View

Finley K, Edeen P, Foss M, Gross E, Ghbeish N, Palmer R . Dissatisfaction encodes a tailless-like nuclear receptor expressed in a subset of CNS neurons controlling Drosophila sexual behavior. Neuron. 1999; 21(6):1363-74. DOI: 10.1016/s0896-6273(00)80655-8. View

Hartmann B, Reichert H, Walldorf U . Interaction of gap genes in the Drosophila head: tailless regulates expression of empty spiracles in early embryonic patterning and brain development. Mech Dev. 2001; 109(2):161-72. DOI: 10.1016/s0925-4773(01)00519-6. View

Steingrimsson E, Pignoni F, Liaw G, Lengyel J . Dual role of the Drosophila pattern gene tailless in embryonic termini. Science. 1991; 254(5030):418-21. DOI: 10.1126/science.1925599. View

10.

Sun G, Yu R, Evans R, Shi Y . Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc Natl Acad Sci U S A. 2007; 104(39):15282-7. PMC: 2000559. DOI: 10.1073/pnas.0704089104. View

11.

Chen Y, Chiang C, Weng L, Lengyel J, Liaw G . Tramtrack69 is required for the early repression of tailless expression. Mech Dev. 2002; 116(1-2):75-83. DOI: 10.1016/s0925-4773(02)00143-0. View

12.

Chen Y, Lin S, Chen Y, Chiang C, Liaw G . The Torso signaling pathway modulates a dual transcriptional switch to regulate tailless expression. Nucleic Acids Res. 2009; 37(4):1061-72. PMC: 2651784. DOI: 10.1093/nar/gkn1036. View

13.

Chu Y, Hughes S, Chan-Ling T . Differentiation and migration of astrocyte precursor cells and astrocytes in human fetal retina: relevance to optic nerve coloboma. FASEB J. 2001; 15(11):2013-5. DOI: 10.1096/fj.00-0868fje. View

14.

Young K, Berry M, Mahaffey C, Saionz J, Hawes N, Chang B . Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent. Behav Brain Res. 2002; 132(2):145-58. PMC: 2862907. DOI: 10.1016/s0166-4328(01)00413-2. View

15.

Shi Y, Lan F, Matson C, Mulligan P, Whetstine J, Cole P . Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004; 119(7):941-53. DOI: 10.1016/j.cell.2004.12.012. View

16.

Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang S . PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997; 275(5308):1943-7. DOI: 10.1126/science.275.5308.1943. View

17.

Mangelsdorf D, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K . The nuclear receptor superfamily: the second decade. Cell. 1995; 83(6):835-9. PMC: 6159888. DOI: 10.1016/0092-8674(95)90199-x. View

18.

Green P, Liaw G, Rudolph K, Lengyel J, Hartenstein V . Control of early neurogenesis of the Drosophila brain by the head gap genes tll, otd, ems, and btd. Dev Biol. 1997; 182(2):270-83. DOI: 10.1006/dbio.1996.8475. View

19.

Groszer M, Erickson R, Scripture-Adams D, Dougherty J, Le Belle J, Zack J . PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2005; 103(1):111-6. PMC: 1325011. DOI: 10.1073/pnas.0509939103. View

20.

Yun K, Potter S, Rubenstein J . Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. Development. 2000; 128(2):193-205. DOI: 10.1242/dev.128.2.193. View