The Role of HLA-G in Immunity and Hematopoiesis

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2010 Dec 1

PMID 21116680

Citations 20

Authors

Edgardo D Carosella

Silvia Gregori

Nathalie Rouas-Freiss

Joel LeMaoult

Catherine Menier

Benoit Favier

Affiliations

Soon will be listed here.

Abstract

The non-classical HLA class I molecule HLA-G was initially shown to play a major role in feto-maternal tolerance. Since this discovery, it has been established that HLA-G is a tolerogenic molecule which participates to the control of the immune response. In this review, we summarize the recent advances on (1) the multiple structures of HLA-G, which are closely associated with their role in the inhibition of NK cell cytotoxicity, (2) the factors that regulate the expression of HLA-G and its receptors, (3) the mechanism of action of HLA-G at the immunological synapse and through trogocytosis, and (4) the generation of suppressive cells through HLA-G. Moreover, we also review recent findings on the non-immunological functions of HLA-G in erythropoiesis and angiogenesis.

Citing Articles

The Multifaced Actions of Curcumin in Pregnancy Outcome.

Tossetta G, Fantone S, Giannubilo S, Marzioni D Antioxidants (Basel). 2021; 10(1).

PMID: 33477354 PMC: 7830020. DOI: 10.3390/antiox10010126.

Puzzling out the COVID-19: Therapy targeting HLA-G and HLA-E.

Zidi I Hum Immunol. 2020; 81(12):697-701.

PMID: 33046268 PMC: 7539797. DOI: 10.1016/j.humimm.2020.10.001.

Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug Delivery.

Almeida-Porada G, Atala A, Porada C Mol Ther Methods Clin Dev. 2020; 16:204-224.

PMID: 32071924 PMC: 7012781. DOI: 10.1016/j.omtm.2020.01.005.

Heterogeneity of HLA-G Expression in Cancers: Facing the Challenges.

Lin A, Yan W Front Immunol. 2018; 9:2164.

PMID: 30319626 PMC: 6170620. DOI: 10.3389/fimmu.2018.02164.

The Folate Cycle As a Cause of Natural Killer Cell Dysfunction and Viral Etiology in Type 1 Diabetes.

Bayer A, Fraker C Front Endocrinol (Lausanne). 2017; 8:315.

PMID: 29218028 PMC: 5703744. DOI: 10.3389/fendo.2017.00315.

References

Kissa K, Herbomel P . Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature. 2010; 464(7285):112-5. DOI: 10.1038/nature08761. View

Schleinitz N, March M, Long E . Recruitment of activation receptors at inhibitory NK cell immune synapses. PLoS One. 2008; 3(9):e3278. PMC: 2538587. DOI: 10.1371/journal.pone.0003278. View

Gleissner C, Dengler T . Induction of ILT expression on nonprofessional antigen presenting cells: Clinical applications. Hum Immunol. 2009; 70(5):357-9. DOI: 10.1016/j.humimm.2009.01.025. View

Boyson J, Erskine R, Whitman M, Chiu M, Lau J, Koopman L . Disulfide bond-mediated dimerization of HLA-G on the cell surface. Proc Natl Acad Sci U S A. 2002; 99(25):16180-5. PMC: 138585. DOI: 10.1073/pnas.212643199. View

Riteau B, Rouas-Freiss N, Menier C, Paul P, Dausset J, Carosella E . HLA-G2, -G3, and -G4 isoforms expressed as nonmature cell surface glycoproteins inhibit NK and antigen-specific CTL cytolysis. J Immunol. 2001; 166(8):5018-26. DOI: 10.4049/jimmunol.166.8.5018. View

Carosella E, Moreau P, LeMaoult J, Rouas-Freiss N . HLA-G: from biology to clinical benefits. Trends Immunol. 2008; 29(3):125-32. DOI: 10.1016/j.it.2007.11.005. View

Naji A, Le Rond S, Durrbach A, Krawice-Radanne I, Creput C, Daouya M . CD3+CD4low and CD3+CD8low are induced by HLA-G: novel human peripheral blood suppressor T-cell subsets involved in transplant acceptance. Blood. 2007; 110(12):3936-48. DOI: 10.1182/blood-2007-04-083139. View

Colucci F, Rosmaraki E, Bregenholt S, Samson S, Di Bartolo V, Turner M . Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms. J Exp Med. 2001; 193(12):1413-24. PMC: 2193296. DOI: 10.1084/jem.193.12.1413. View

Rouas-Freiss N, Goncalves R, Menier C, Dausset J, Carosella E . Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis. Proc Natl Acad Sci U S A. 1997; 94(21):11520-5. PMC: 23525. DOI: 10.1073/pnas.94.21.11520. View

10.

Lopez A, Alegre E, LeMaoult J, Carosella E, Gonzalez A . Regulatory role of tryptophan degradation pathway in HLA-G expression by human monocyte-derived dendritic cells. Mol Immunol. 2006; 43(14):2151-60. DOI: 10.1016/j.molimm.2006.01.007. View

11.

Pot C, Jin H, Awasthi A, Liu S, Lai C, Madan R . Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol. 2009; 183(2):797-801. PMC: 2768608. DOI: 10.4049/jimmunol.0901233. View

12.

Baxter E, Scott L, Campbell P, East C, Fourouclas N, Swanton S . Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005; 365(9464):1054-61. DOI: 10.1016/S0140-6736(05)71142-9. View

13.

Luque J, Torres M, Aumente M, Lozano J, Garcia-Jurado G, Gonzalez R . sHLA-G levels in the monitoring of immunosuppressive therapy and rejection following heart transplantation. Transpl Immunol. 2006; 17(1):70-3. DOI: 10.1016/j.trim.2006.09.009. View

14.

Lila N, Amrein C, Guillemain R, Chevalier P, Latremouille C, Fabiani J . Human leukocyte antigen-G expression after heart transplantation is associated with a reduced incidence of rejection. Circulation. 2002; 105(16):1949-54. DOI: 10.1161/01.cir.0000015075.89984.46. View

15.

Howangyin K, Alegre E, Daouya M, Favier B, Carosella E, LeMaoult J . Different functional outcomes of intercellular membrane transfers to monocytes and T cells. Cell Mol Life Sci. 2010; 67(7):1133-45. PMC: 11115494. DOI: 10.1007/s00018-009-0239-4. View

16.

Blaschitz A, Lenfant F, Mallet V, Hartmann M, Bensussan A, Geraghty D . Endothelial cells in chorionic fetal vessels of first trimester placenta express HLA-G. Eur J Immunol. 1998; 27(12):3380-8. DOI: 10.1002/eji.1830271237. View

17.

Moreau P, Carosella E, Teyssier M, Prost S, Gluckman E, Dausset J . Soluble HLA-G molecule. An alternatively spliced HLA-G mRNA form candidate to encode it in peripheral blood mononuclear cells and human trophoblasts. Hum Immunol. 1995; 43(3):231-6. DOI: 10.1016/0198-8859(95)00009-s. View

18.

Menier C, Prevot S, Carosella E, Rouas-Freiss N . Human leukocyte antigen-G is expressed in advanced-stage ovarian carcinoma of high-grade histology. Hum Immunol. 2009; 70(12):1006-9. DOI: 10.1016/j.humimm.2009.07.021. View

19.

LeMaoult J, Caumartin J, Carosella E . Exchanges of membrane patches (trogocytosis) split theoretical and actual functions of immune cells. Hum Immunol. 2007; 68(4):240-3. DOI: 10.1016/j.humimm.2006.11.001. View

20.

Menier C, Rouas-Freiss N, Favier B, LeMaoult J, Moreau P, Carosella E . Recent advances on the non-classical major histocompatibility complex class I HLA-G molecule. Tissue Antigens. 2010; 75(3):201-6. DOI: 10.1111/j.1399-0039.2009.01438.x. View