Augmentation of Regulatory B Cell Activity in Experimental Allergic Encephalomyelitis by Glatiramer Acetate

Overview

Journal J Neuroimmunol

Specialty Neurology

Date 2010 Nov 30

PMID 21111489

Citations 20

Authors

Sakhina Begum-Haque

Marc Christy

Javier Ochoa-Reparaz

Elizabeth C Nowak

Daniel Mielcarz

Azizul Haque

Lloyd H Kasper

Affiliations

Soon will be listed here.

Abstract

We recently showed that B cells reduce CNS inflammation in mice with experimental allergic encephalomyelitis (EAE). Here, we demonstrate that adoptively transferred CD5/CD19+ B cells protect against EAE severity. Furthermore, we show that glatiramer acetate (GA), a therapeutic for relapsing multiple sclerosis treatment, amplifies this effect. Transfer of GA-conditioned B cells leads to increased production of immunoregulatory cytokines and reduced CNS inflammation, as well as decreased expression of the chemokine receptor, CXCR5, and elevated BDNF expression in the CNS. Thus B cells can protect against EAE, and GA augments this effect in maintaining immune homeostasis and controlling EAE disease progression.

Citing Articles

Intruders or protectors - the multifaceted role of B cells in CNS disorders.

Aspden J, Murphy M, Kashlan R, Xiong Y, Poznansky M, Sirbulescu R Front Cell Neurosci. 2024; 17:1329823.

PMID: 38269112 PMC: 10806081. DOI: 10.3389/fncel.2023.1329823.

The role of B cells in the immunopathogenesis of multiple sclerosis.

Gharibi T, Babaloo Z, Hosseini A, Marofi F, Ebrahimi-Kalan A, Jahandideh S Immunology. 2020; 160(4):325-335.

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Impact of Glatiramer Acetate on B Cell-Mediated Pathogenesis of Multiple Sclerosis.

Kuerten S, Jackson L, Kaye J, Vollmer T CNS Drugs. 2018; 32(11):1039-1051.

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Deciphering the Role of B Cells in Multiple Sclerosis-Towards Specific Targeting of Pathogenic Function.

Lehmann-Horn K, Kinzel S, Weber M Int J Mol Sci. 2017; 18(10).

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B Cell-Directed Therapeutics in Multiple Sclerosis: Rationale and Clinical Evidence.

Kinzel S, Weber M CNS Drugs. 2016; 30(12):1137-1148.

PMID: 27844213 DOI: 10.1007/s40263-016-0396-6.

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