» Articles » PMID: 21109518

Evaluating Antirheumatic Treatments Using Synovial Biopsy: a Recommendation for Standardisation to Be Used in Clinical Trials

Abstract

Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.

Citing Articles

EULAR standardised training model for ultrasound-guided, minimally invasive synovial tissue biopsy procedures in large and small joints.

Moller I, Largo R, Bong D, Filer A, Najm A, Alivernini S RMD Open. 2025; 11(1.

PMID: 39832957 PMC: 11749067. DOI: 10.1136/rmdopen-2024-005065.


High-grade synovitis associates with clinical markers and response to therapy in chronic inflammatory arthritis: analysis of a synovial biomarkers prospective cohort study.

Garaffoni C, Tamussin M, Calciolari I, Lanza G, Bortoluzzi A, Scire C Front Immunol. 2024; 14:1298583.

PMID: 38274811 PMC: 10808827. DOI: 10.3389/fimmu.2023.1298583.


In-Office Needle Arthroscopic Synovial Biopsy Is an Effective Diagnostic Tool in Patients With Inflammatory Arthritis.

Andreozzi V, Monaco E, Garufi C, Spinelli F, Rossi G, Dagget M Arthrosc Sports Med Rehabil. 2022; 4(6):e2099-e2106.

PMID: 36579034 PMC: 9791868. DOI: 10.1016/j.asmr.2022.10.003.


The preferred technique for knee synovium biopsy and synovial fluid arthrocentesis.

Fuentes-Braesch M, Tuijthof G, Emans P, Emanuel K Rheumatol Int. 2022; 43(10):1767-1779.

PMID: 36513849 DOI: 10.1007/s00296-022-05256-4.


Increased Frequency of CD4 Follicular Helper T and CD8 Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis.

Anang D, Ramwadhdoebe T, Hahnlein J, van Kuijk B, Smits N, van Lienden K Cells. 2022; 11(7).

PMID: 35406668 PMC: 8997933. DOI: 10.3390/cells11071104.