Correlation of Biomarkers in Head and Neck Squamous Cell Carcinoma

Overview

Journal Otolaryngol Head Neck Surg

Publisher Wiley

Specialties General Surgery
Otorhinolaryngology

Date 2010 Nov 27

PMID 21109080

Citations 4

Authors

Gary M Tse

Ann D King

Alex M C Yu

Christopher C F Lam

Anthony W H Chan

George G Chen

David K Yeung

Kwok-Hung Yu

Kunwar S Bhatia

Amy B W Chan

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the relationship of functional magnetic resonance imaging (MRI) parameters, including choline/creatine ratio (Cho/Cr) and apparent diffusion coefficient (ADC) with protein expression of 10 common tumor and prognostic markers in head and neck squamous cell carcinoma.

Study Design: Cross-sectional study.

Setting: University hospital.

Subjects And Methods: The Cho/Cr and ADC obtained from 74 patients with head and neck squamous cell carcinoma were correlated with the expression level of the 10 protein markers as determined by immunohistochemistry.

Results: Cho/Cr showed significant positive correlations with cyclooxygenase 2 in primary tumors (r = 0.714), and epidermal growth factor receptor in metastatic cervical lymph nodes (r = 0.522). ADC showed significant (r = -0.591) negative correlation with human epidermal growth factor receptor 2 in metastatic cervical lymph nodes.

Conclusion: There are relationships between protein and functional MRI markers. Future research in this direction may improve our understanding of the cancer micro-environment.

Citing Articles

The Prediction of Biological Features Using Magnetic Resonance Imaging in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

van der Hulst H, Jansen R, Vens C, Bos P, Schats W, de Jong M Cancers (Basel). 2023; 15(20).

PMID: 37894447 PMC: 10605807. DOI: 10.3390/cancers15205077.

Correlation between F-FDG PET/MR parameters with the expression level of epidermal growth factor receptor and the diagnostic value of PET/MR in head and neck squamous cell carcinoma.

Chen Y, Dang H, Wu X, Zhang Z, Shi X, Zhang T Heliyon. 2023; 9(4):e14822.

PMID: 37089359 PMC: 10119563. DOI: 10.1016/j.heliyon.2023.e14822.

Functional magnetic resonance imaging of head and neck cancer: Performance and potential.

Beltagi A, Elsotouhy A, Own A, Abdelfattah W, Nair K, Vattoth S Neuroradiol J. 2018; 32(1):36-52.

PMID: 30396315 PMC: 6327365. DOI: 10.1177/1971400918808546.

Correlation of a priori DCE-MRI and (1)H-MRS data with molecular markers in neck nodal metastases: Initial analysis.

Jansen J, Carlson D, Lu Y, Stambuk H, Moreira A, Singh B Oral Oncol. 2012; 48(8):717-22.

PMID: 22366441 PMC: 3368067. DOI: 10.1016/j.oraloncology.2012.02.001.