Inhalation Exposure to Nanosized and Fine TiO2 Particles Inhibits Features of Allergic Asthma in a Murine Model

Overview

Journal Part Fibre Toxicol

Publisher Biomed Central

Specialty Toxicology

Date 2010 Nov 27

PMID 21108815

Citations 28

Authors

Elina M Rossi

Lea Pylkkanen

Antti J Koivisto

Heli Nykasenoja

Henrik Wolff

Kai Savolainen

Harri Alenius

Affiliations

Soon will be listed here.

Abstract

Background: Nanotechnology and engineered nanomaterials (ENM) are here to stay. Recent evidence suggests that exposure to environmental particulate matter exacerbates symptoms of asthma. In the present study we investigated the modulatory effects of titanium dioxide particle exposure in an experimental allergic asthma.

Methods: Nonallergic (healthy) and ovalbumin-sensitized (asthmatic) mice were exposed via inhalation to two different sizes of titanium dioxide particles, nanosized (nTiO2) and fine (fTiO2), for 2 hours a day, three days a week, for four weeks at a concentration of 10 mg/m3. Different endpoints were analysed to evaluate the immunological status of the mice.

Results: Healthy mice elicited pulmonary neutrophilia accompanied by significantly increased chemokine CXCL5 expression when exposed to nTiO2. Surprisingly, allergic pulmonary inflammation was dramatically suppressed in asthmatic mice which were exposed to nTiO2 or fTiO2 particles - i.e. the levels of leucocytes, cytokines, chemokines and antibodies characteristic to allergic asthma were substantially decreased.

Conclusions: Our results suggest that repeated airway exposure to TiO2 particles modulates the airway inflammation depending on the immunological status of the exposed mice.

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References

Hamelmann E, Schwarze J, Takeda K, Oshiba A, Larsen G, Irvin C . Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med. 1997; 156(3 Pt 1):766-75. DOI: 10.1164/ajrccm.156.3.9606031. View

Yazdanbakhsh M, Kremsner P, van Ree R . Allergy, parasites, and the hygiene hypothesis. Science. 2002; 296(5567):490-4. DOI: 10.1126/science.296.5567.490. View

Warheit D, Yuen I, Kelly D, Snajdr S, Hartsky M . Subchronic inhalation of high concentrations of low toxicity, low solubility particulates produces sustained pulmonary inflammation and cellular proliferation. Toxicol Lett. 1996; 88(1-3):249-53. DOI: 10.1016/0378-4274(96)82678-6. View

Boffetta P, Soutar A, Cherrie J, Granath F, Andersen A, Anttila A . Mortality among workers employed in the titanium dioxide production industry in Europe. Cancer Causes Control. 2004; 15(7):697-706. DOI: 10.1023/B:CACO.0000036188.23970.22. View

Geiser M, Casaulta M, Kupferschmid B, Schulz H, Semmler-Behnke M, Kreyling W . The role of macrophages in the clearance of inhaled ultrafine titanium dioxide particles. Am J Respir Cell Mol Biol. 2007; 38(3):371-6. DOI: 10.1165/rcmb.2007-0138OC. View

Larsen S, Roursgaard M, Jensen K, Nielsen G . Nano titanium dioxide particles promote allergic sensitization and lung inflammation in mice. Basic Clin Pharmacol Toxicol. 2009; 106(2):114-7. PMC: 2816362. DOI: 10.1111/j.1742-7843.2009.00473.x. View

Rossi E, Pylkkanen L, Koivisto A, Vippola M, Jensen K, Miettinen M . Airway exposure to silica-coated TiO2 nanoparticles induces pulmonary neutrophilia in mice. Toxicol Sci. 2009; 113(2):422-33. DOI: 10.1093/toxsci/kfp254. View

Chen X, Mao S . Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Chem Rev. 2007; 107(7):2891-959. DOI: 10.1021/cr0500535. View

Mitchell L, Gao J, Vander Wal R, Gigliotti A, Burchiel S, McDonald J . Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol Sci. 2007; 100(1):203-14. DOI: 10.1093/toxsci/kfm196. View

10.

Fedulov A, Leme A, Yang Z, Dahl M, Lim R, Mariani T . Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility. Am J Respir Cell Mol Biol. 2007; 38(1):57-67. PMC: 2176127. DOI: 10.1165/rcmb.2007-0124OC. View

11.

Nordenhall C, Pourazar J, Ledin M, Levin J, Sandstrom T, Adelroth E . Diesel exhaust enhances airway responsiveness in asthmatic subjects. Eur Respir J. 2001; 17(5):909-15. DOI: 10.1183/09031936.01.17509090. View

12.

Grassian V, OShaughnessy P, Adamcakova-Dodd A, Pettibone J, Thorne P . Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm. Environ Health Perspect. 2007; 115(3):397-402. PMC: 1849915. DOI: 10.1289/ehp.9469. View

13.

Eum S, Maghni K, Tolloczko B, Eidelman D, Martin J . IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2004; 288(3):L576-84. DOI: 10.1152/ajplung.00380.2003. View

14.

Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Cogliano V . Carcinogenicity of carbon black, titanium dioxide, and talc. Lancet Oncol. 2006; 7(4):295-6. DOI: 10.1016/s1470-2045(06)70651-9. View

15.

Ryan J, Bateman H, Stover A, Gomez G, Norton S, Zhao W . Fullerene nanomaterials inhibit the allergic response. J Immunol. 2007; 179(1):665-72. DOI: 10.4049/jimmunol.179.1.665. View

16.

Thatcher T, Benson R, Phipps R, Sime P . High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function. Am J Physiol Lung Cell Mol Physiol. 2008; 295(3):L412-21. PMC: 2536795. DOI: 10.1152/ajplung.00392.2007. View

17.

Weinmayr G, Weiland S, Bjorksten B, Brunekreef B, Buchele G, Cookson W . Atopic sensitization and the international variation of asthma symptom prevalence in children. Am J Respir Crit Care Med. 2007; 176(6):565-74. DOI: 10.1164/rccm.200607-994OC. View

18.

Hext P, Tomenson J, Thompson P . Titanium dioxide: inhalation toxicology and epidemiology. Ann Occup Hyg. 2005; 49(6):461-72. DOI: 10.1093/annhyg/mei012. View

19.

Oberdorster G . Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health. 2001; 74(1):1-8. DOI: 10.1007/s004200000185. View

20.

Gavett S, Koren H . The role of particulate matter in exacerbation of atopic asthma. Int Arch Allergy Immunol. 2001; 124(1-3):109-12. DOI: 10.1159/000053685. View