The Effect of Genital and Lower Urinary Tract Symptoms on Steroid Receptor Expression in Women with Genital Prolapse

Overview

Journal Int Urogynecol J

Publisher Springer

Specialties Gynecology & Obstetrics
Urology

Date 2010 Nov 26

PMID 21107812

Citations 5

Authors

Christine Elisabeth Skala

Ilka Brigitte Petry

Stefan Albrich

Alexander Puhl

Gert Naumann

Heinz Koelbl

Affiliations

Soon will be listed here.

Abstract

Introduction And Hypothesis: This study evaluates the expression of estrogen receptor (ER) isoforms alpha (α) and beta (β) and progesterone receptor (PR) in vaginal and periurethral tissue in women with genital prolapse in relation to genital and lower urinary tract symptoms (LUTS).

Methods: Forty-seven postmenopausal women without systemic estrogen therapy underwent pelvic organ prolapse quantification and urodynamic assessment. LUTS were evaluated by CATI questionnaire. Biopsies from vaginal and periurethral tissue were obtained during prolapse surgery. The steroid receptor gene expression was measured by RT-PCR.

Results: The expression of PR in periurethral and ER β in vaginal tissue varied with prolapse extent. Nulliparous women showed a significantly higher expression of PR in periurethral tissue. Women with a positive stress test and those with overactive bladder symptoms showed a significantly lower amount of PR in vaginal tissue.

Conclusion: Changes in PR expression in vaginal or periurethral tissue might be a marker of structural and endocrine changes.

Citing Articles

The Current Evidence on the Association Between the Urinary Microbiome and Urinary Incontinence in Women.

Govender Y, Gabriel I, Minassian V, Fichorova R Front Cell Infect Microbiol. 2019; 9:133.

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Multidisciplinary overview of vaginal atrophy and associated genitourinary symptoms in postmenopausal women.

Goldstein I, Dicks B, Kim N, Hartzell R Sex Med. 2014; 1(2):44-53.

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Urethral dysfunction in female mice with estrogen receptor β deficiency.

Chen Y, Chen C, Yeh S, Lin Y, Wu Y, Hsieh W PLoS One. 2014; 9(9):e109058.

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Interferon-γ and its pathway-associated gene expression in the vaginal tissue of premenopausal females with pelvic organ prolapse.

Zhao B, Yan J, Wu H, Zhou Y, Xu D, Hu M Exp Ther Med. 2014; 8(4):1145-1149.

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Moon Y, Bai S, Jung C, Kim C Int Urogynecol J. 2013; 24(11):1961-7.

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