Relationship Between Intestinal Gas and the Development of Right Colonic Diverticula

Overview

Journal J Neurogastroenterol Motil

Date 2010 Nov 25

PMID 21103424

Citations 9

Authors

Sung-Ill Jang

Jie-Hyun Kim

Young Hoon Youn

Hyojin Park

Sang In Lee

Jeffrey L Conklin

Affiliations

Soon will be listed here.

Abstract

Backgrounds/aims: High intraluminal pressure has been reported to cause left colonic diverticula. However, the pathophysiology of right colonic diverticula is still unclear. Methane gas has been reported to delay small intestinal transit and to increase intraluminal pressure. The aim of this study was to evaluate the relationship between right colonic diverticula and intestinal gas produced by enteric bacteria.

Methods: Lactulose breath tests were performed in 30 patients who were diagnosed with right colonic diverticula via colonoscopy. The control group consisted of 30 healthy adults with no specific symptoms or medical histories. A hydrogen or methane producer was defined in 2 ways: either one that exhibited a breath hydrogen level ≥ 20 ppm (methane ≥ 10 ppm) baseline or one that exhibited an increase in breath hydrogen ≥ 20 ppm (methane ≥ 10 ppm) above baseline within the first 90 minutes of the test.

Results: The lactulose breath test (LBT) positivity in the diverticular group and the control group were 40.0% and 33.3%, respectively, without a statistically significant difference. The concentrations of methane and hydrogen gas measured by LBT increased over time, but there was no significant difference between the control and the diverticular groups.

Conclusions: There was no significant relationship between right colonic diverticula and intestinal gases produced by enteric bacteria. However, time-dependent formation of diverticula should be taken into consideration, therefore long-term, large-scale follow-up studies may reveal further pathogenesis of right colonic diverticulosis.

Citing Articles

The Epidemiology and Etiology of Right-Sided Colonic Diverticulosis: A Review.

Turner G, OGrady M, Purcell R, Frizelle F Ann Coloproctol. 2021; 37(4):196-203.

PMID: 34284562 PMC: 8391037. DOI: 10.3393/ac.2021.00192.0027.

Bacteria and Methanogens in the Human Microbiome: a Review of Syntrophic Interactions.

Djemai K, Drancourt M, Alou M Microb Ecol. 2021; 83(3):536-554.

PMID: 34169332 DOI: 10.1007/s00248-021-01796-7.

Breath methane to hydrogen ratio as a surrogate marker of intestinal dysbiosis in head and neck cancer.

Dharmawardana N, Goddard T, Woods C, Watson D, Butler R, Ooi E Sci Rep. 2020; 10(1):15010.

PMID: 32929151 PMC: 7490703. DOI: 10.1038/s41598-020-72115-2.

Logical hypothesis: Low FODMAP diet to prevent diverticulitis.

Uno Y, van Velkinburgh J World J Gastrointest Pharmacol Ther. 2016; 7(4):503-512.

PMID: 27867683 PMC: 5095569. DOI: 10.4292/wjgpt.v7.i4.503.

Irritable Bowel Syndrome, Particularly the Constipation-Predominant Form, Involves an Increase in , Which Is Associated with Higher Methane Production.

Ghoshal U, Shukla R, Srivastava D, Ghoshal U Gut Liver. 2016; 10(6):932-938.

PMID: 27458176 PMC: 5087933. DOI: 10.5009/gnl15588.

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