The Effects of Photodynamic Therapy in Upper-gastrointestinal Malignant Diseases

Overview

Journal Gut Liver

Specialty Gastroenterology

Date 2010 Nov 25

PMID 21103293

Citations 5

Authors

Key Hyeon Kim

Jong-Jae Park

Affiliations

Soon will be listed here.

Abstract

Photodynamic therapy (PDT) is a promising new modality that utilizes the combination of a photosensitizing chemical and visible light for the management of various solid malignancies, including gastrointestinal (GI) cancer. PDT has some advantages over chemotherapy in terms of its greater safety and lower toxicity in the treatment of malignant lesions. However, PDT has not been used widely for treating upper GI cancer due to its relatively low cost-effectiveness and anatomical characteristics of the GI system. Nevertheless, PDT may be an effective alternative therapy for early upper-GI cancer patients who are at a high risk of curative surgical resection or systemic chemotherapy. In some clinical studies, PDT for various upper GI cancer showed positiveresults. To improve the efficacy of PDT for upper GI cancer, development of photosensitezer and light delivery system is needed.

Citing Articles

Progress in Clinical Trials of Photodynamic Therapy for Solid Tumors and the Role of Nanomedicine.

Alsaab H, Alghamdi M, Alotaibi A, Alzhrani R, Alwuthaynani F, Althobaiti Y Cancers (Basel). 2020; 12(10).

PMID: 33003374 PMC: 7601252. DOI: 10.3390/cancers12102793.

Application of photodynamic therapy for liver malignancies.

Zou H, Wang F, Zhou J, Liu X, He Q, Wang C J Gastrointest Oncol. 2020; 11(2):431-442.

PMID: 32399283 PMC: 7212095. DOI: 10.21037/jgo.2020.02.10.

The study of killing effect and inducing apoptosis of 630-nm laser on lung adenocarcinoma A549 cells mediated by hematoporphyrin derivatives in vitro.

Lin C, Zhang Y, Zhu X, Cui S, Cao Y, Li R Lasers Med Sci. 2019; 35(1):71-78.

PMID: 31049741 DOI: 10.1007/s10103-019-02794-5.

Antitumor activity of photodynamic therapy performed with nanospheres containing zinc-phthalocyanine.

Portilho F, Cavalcanti C, Miranda-Vilela A, Estevanato L, Figueiro Longo J, Santos M J Nanobiotechnology. 2013; 11:41.

PMID: 24341795 PMC: 3881021. DOI: 10.1186/1477-3155-11-41.

Photodynamic therapy in gastroenterology.

Shishkova N, Kuznetsova O, Berezov T J Gastrointest Cancer. 2013; 44(3):251-9.

PMID: 23645540 DOI: 10.1007/s12029-013-9496-4.

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