Magnetic Resonance Imaging Quantification of Liver Iron

Overview

Journal Magn Reson Imaging Clin N Am

Specialty Radiology

Date 2010 Nov 25

PMID 21094445

Citations 91

Authors

Claude B Sirlin

Scott B Reeder

Affiliations

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Abstract

Iron overload is the histologic hallmark of hereditary hemochromatosis and transfusional hemosiderosis but also may occur in chronic hepatopathies. This article provides an overview of iron deposition and diseases where liver iron overload is clinically relevant. Next, this article reviews why quantitative noninvasive biomarkers of liver iron would be beneficial. Finally, we describe current state-of-the-art methods for quantifying iron with MR imaging and review remaining challenges and unsolved problems.

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