Polymorphisms in Chemokine and Receptor Genes and Gastric Cancer Risk and Survival in a High Risk Polish Population

Overview

Journal Scand J Gastroenterol

Publisher Informa Healthcare

Specialty Gastroenterology

Date 2010 Nov 25

PMID 21091093

Citations 11

Authors

Andrew J Gawron

Angela J Fought

Jolanta Lissowska

Weimin Ye

Xiao Zhang

Wong-Ho Chow

Laura E Beane Freeman

Lifang Hou

Affiliations

Soon will be listed here.

Abstract

Objective: To examine if genetic variations in chemokine receptor and ligand genes are associated with gastric cancer risk and survival.

Methods: The study included 298 cases and 417 controls from a population-based study of gastric cancer conducted in Warsaw, Poland in 1994-1996. We investigated seven single nucleotide polymorphisms in a chemokine ligand (CXCL12) and chemokine receptor (CCR2, CCR5, CX3CR1) genes and one frameshift deletion (CCR5) in blood leukocyte DNA in relation to gastric cancer risk and survival. Genotyping was conducted at the NCI Core Genotyping Facility. Odds ratios and 95% confidence intervals were computed using univariate and multivariate logistic regression models. Survival analysis was performed using Cox proportional hazards models.

Results: Gastric cancer risk was not associated with single chemokine polymorphisms. A CCR5 haplotype that contained the common alleles of IVS1+151 G>T (rs2734648), IVS2+80 C>T (rs1800024) and minor allele of IVS1+246 A>G (rs1799987) was associated with a borderline significantly increased risk (OR = 1.5, 95% CI: 1.0?2.2). For gastric cancer cases, there was a greater risk of death for carriers of the minor alleles of CCR2 Ex2+241 G>A (rs1799864) (HR = 1.5, 95% CI: 1.1-2.1) and CCR5 IVS2+80 C>T (rs1800024) (HR = 1.5, 95% CI: 1.1-2.1). Carriers of the CCR5 minor allele of IVS1+151 G>T (rs2734648) had a decreased risk of death compared to homozygote carriers of the common allele (HR = 0.8, 95% CI: 0.6-1.0).

Conclusions: Our findings do not support an association between gastric cancer risk and single chemokine genetic variation. The observed associations between cancer risk and a CCR5 haplotype and between survival and polymorphisms in CCR2 and CCR5 need replication in future studies.

Citing Articles

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Association analysis and allelic distribution of deletion in CC chemokine receptor 5 gene (CCR5Δ32) among breast cancer patients of Pakistan.

Fatima F, Saleem S, Hameed A, Haider G, Zaidi S, Kanwal M Mol Biol Rep. 2019; 46(2):2387-2394.

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Role of CCL5 and CCR5 gene polymorphisms in epidermal growth factor receptor signalling blockade in metastatic colorectal cancer: analysis of the FIRE-3 trial.

Suenaga M, Stintzing S, Cao S, Zhang W, Yang D, Ning Y Eur J Cancer. 2018; 107:100-114.

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Genetic variants in CCL5 and CCR5 genes and serum VEGF-A levels predict efficacy of bevacizumab in metastatic colorectal cancer patients.

Suenaga M, Cao S, Zhang W, Yang D, Ning Y, Okazaki S Int J Cancer. 2018; 144(10):2567-2577.

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C-C motif chemokine receptors in gastric cancer.

Ryu H, Baek S, Moon J, Jo I, Kim N, Lee H Mol Clin Oncol. 2017; 8(1):3-8.

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