Evaluation of 25-hydroxyvitamin D Serum Levels in Patients with Fibromyalgia

Background: Fibromyalgia (FM) is a condition characterized by chronic widespread musculoskeletal pain often associated with sleep disorders and mood and whose pathophysiology is still not clearly defined. In recent years, some studies have hinted at a possible association between different types of pain, including the pain present in FM, with vitamin D deficiency.

Objective And Methods: The present work consisted of a cross-sectional study aimed at evaluating 25-hydroxyvitamin D (25(OH)D) serum levels in 87 patients with FM, as compared with a control group composed of 92 age- and sex-matched subjects with no chronic musculoskeletal pain. Clinical and laboratory variables that could affect the status of vitamin D were also considered.

Results: There was no statistically significant difference between groups either with respect to mean serum concentration of 25(OH)D or as to the classification of levels as deficient, insufficient, or sufficient. There was no correlation of 25(OH)D levels with pain intensity.

Conclusion: This study showed that light to moderate deficient and insufficient 25(OH)D levels are not found more commonly in patients with FM.