» Articles » PMID: 2108043

Sequential Appearance of Gamma/delta- and Alpha/beta-bearing T Cells in the Peritoneal Cavity During an I.p. Infection with Listeria Monocytogenes

Overview
Journal Eur J Immunol
Date 1990 Mar 1
PMID 2108043
Citations 66
Authors
Affiliations
Soon will be listed here.
Abstract

To search for a potential role of T cell antigen receptor (TcR) gamma/delta-bearing cells in host-defense against Listeria monocytogenes, we analyzed the sequential appearance of gamma/delta and alpha/beta T cell in the peritoneal exudate cells (PEC) during an i.p. infection with sublethal dose (2 X 10(3) of viable Listeria organisms in mice. The PEC on day 1 after the infection consisted of 48% macrophages and 50% lymphocytes, most of which were surface IgM+ (B) cells. The number of PEC increased to the maximal level by day 3. The PEC at this stage contained an appreciable number of CD3+ T cells in addition to a large number of macrophages. Of the CD3+ cells, the proportion of CD4- CD8- cells, most of which expressed no TcR alpha/beta, increased to the maximal level on day 3 after the infection. In correlation with an increased number of CD3+ CD4- CD8- TcR alpha/beta- cells, high level of TcR gamma/delta chain gene messages was detected in the nonadherent population of the PEC on this stage. On the other hand, the PEC on day 8 contained an increased number of CD4+ CD8- and CD4- CD8+ cells which expressed TcR alpha/beta chain on their surface. These results suggest that the gamma/delta T cells precede the alpha/beta T cells in appearance during listerial infection. The gamma/delta T cells may be involved at the first line of the host-defense against Listeria.

Citing Articles

γδ T Cells Participating in Nervous Systems: A Story of Jekyll and Hyde.

Li Y, Zhang Y, Zeng X Front Immunol. 2021; 12:656097.

PMID: 33868300 PMC: 8044362. DOI: 10.3389/fimmu.2021.656097.


Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells.

Khairallah C, Chu T, Sheridan B Front Immunol. 2018; 9:2636.

PMID: 30538697 PMC: 6277633. DOI: 10.3389/fimmu.2018.02636.


IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections.

Riol-Blanco L, Lazarevic V, Awasthi A, Mitsdoerffer M, Wilson B, Croxford A J Immunol. 2010; 184(4):1710-20.

PMID: 20083652 PMC: 2829977. DOI: 10.4049/jimmunol.0902796.


Deficiency of gammadelta T lymphocytes contributes to mortality and immunosuppression in sepsis.

Chung C, Watkins L, Funches A, Lomas-Neira J, Cioffi W, Ayala A Am J Physiol Regul Integr Comp Physiol. 2006; 291(5):R1338-43.

PMID: 16793935 PMC: 1592544. DOI: 10.1152/ajpregu.00283.2006.


Identification of novel gammadelta T-cell subsets following bacterial infection in the absence of Vgamma1+ T cells: homeostatic control of gammadelta T-cell responses to pathogen infection by Vgamma1+ T cells.

Newton D, Andrew E, Dalton J, Mears R, Carding S Infect Immun. 2006; 74(2):1097-105.

PMID: 16428757 PMC: 1360339. DOI: 10.1128/IAI.74.2.1097-1105.2006.