The Inductive Effect of Interleukin-4 on IgG4 and IgE Synthesis in Human Peripheral Blood Lymphocytes

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1990 Mar 1

PMID 2107992

Citations 40

Authors

A Ishizaka

Y Sakiyama

M Nakanishi

K Tomizawa

E OSHIKA

K Kojima

Y Taguchi

E Kandil

S Matsumoto

Affiliations

Soon will be listed here.

Abstract

Using murine monoclonal antibodies against human IgG subclasses, specific and sensitive ELISAs assay to quantify the four human IgG subclasses in cell culture supernatants were established. The effect of human recombinant interleukin-4 (IL-4) on the regulation of IgG subclasses by normal peripheral blood lymphocytes was investigated. In addition to the enhancement of IgE synthesis, IL-4 preferentially induced IgG4 synthesis in vitro, whereas IL-4 had no effect on IgG1, IgG2, and IgG3 synthesis. IL-4-induced IgG4 production was blocked in a dose-dependent manner by recombinant interferon-gamma and anti-human IL-4 monoclonal antibody. Collectively, this data indicates that IL-4 plays an important regulatory role in both IgG subclass and IgE synthesis.

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