Ultraviolet Radiation Suppresses Mouse-ear Edema Induced by Topical Application of Arachidonic Acid

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 1990 Jan 1

PMID 2107798

Citations 1

Authors

K Danno

K Toda

K IKAI

T Horio

S Imamura

Affiliations

Soon will be listed here.

Abstract

The effect of ultraviolet (UV) radiation on arachidonic acid (AA) cascade was examined using an in vivo model. Mouse ear lobes were painted with 1 mg AA, and the maximum response of ear swelling was measured 1 h after challenge. Arachidonic-acid-induced ear swelling was significantly suppressed by preexposure to topical psoralen plus noninflammatory doses of long-wave UV radiation (PUVA) or middle-wave UV (UVB) radiation. Ultraviolet radiation may interfere with AA pathways to suppress ear swelling since AA-induced ear swelling is considered to be mediated by metabolites derived from exogenous AA. The results may relate to the therapeutic mechanisms of UV radiation in psoriasis in which the eicosanoid cascade is involved.

Citing Articles

Anti-inflammatory effects of eicosapentaenoic acid on experimental skin inflammation models.

Danno K, IKAI K, Imamura S Arch Dermatol Res. 1993; 285(7):432-5.

PMID: 8304784 DOI: 10.1007/BF00372139.

References

Ashida Y, Saijo T, Kuriki H, Makino H, Terao S, Maki Y . Pharmacological profile of AA-861, a 5-lipoxygenase inhibitor. Prostaglandins. 1983; 26(6):955-72. DOI: 10.1016/0090-6980(83)90157-0. View

BLACK A, Fincham N, Greaves M, Hensby C . Time course changes in levels of arachidonic acid and prostaglandins D2, E2, F2 alpha in human skin following ultraviolet B irradiation. Br J Clin Pharmacol. 1980; 10(5):453-7. PMC: 1430161. DOI: 10.1111/j.1365-2125.1980.tb01788.x. View

Opas E, Bonney R, Humes J . Prostaglandin and leukotriene synthesis in mouse ears inflamed by arachidonic acid. J Invest Dermatol. 1985; 84(4):253-6. DOI: 10.1111/1523-1747.ep12265320. View

Toda K, Danno K, Tachibana T, Horio T . Effect of 8-methoxypsoralen plus long-wave ultraviolet (PUVA) radiation on mast cells. II. In vitro PUVA inhibits degranulation of rat peritoneal mast cells induced by compound 48/80. J Invest Dermatol. 1986; 87(1):113-6. DOI: 10.1111/1523-1747.ep12523611. View

Danno K, Toda K, Horio T . Ultraviolet-B radiation suppresses mast cell degranulation induced by compound 48/80. J Invest Dermatol. 1986; 87(6):775-8. DOI: 10.1111/1523-1747.ep12458843. View

Greaves M, Hensby C, Plummer N, Warin A . The effect of combined ultraviolet A irradiation and oral psoralens (PUVA) on skin arachidonic acid and prostaglandin concentrations in psoriasis [proceedings]. Br J Pharmacol. 1978; 63(2):372P. PMC: 1668374. View

Danno K, Toda K, Horio T . The effect of 8-methoxypsoralen plus long-wave ultraviolet (PUVA) radiation on mast cells: PUVA suppresses degranulation of mouse skin mast cells induced by compound 48/80 or concanavalin A. J Invest Dermatol. 1985; 85(2):110-4. DOI: 10.1111/1523-1747.ep12276497. View

Ruzicka T, Walter J, Printz M . Changes in arachidonic acid metabolism in UV-irradiated hairless mouse skin. J Invest Dermatol. 1983; 81(4):300-3. DOI: 10.1111/1523-1747.ep12519287. View

Young J, Spires D, Bedord C, Wagner B, Ballaron S, De Young L . The mouse ear inflammatory response to topical arachidonic acid. J Invest Dermatol. 1984; 82(4):367-71. DOI: 10.1111/1523-1747.ep12260709. View

10.

Danno K, Fujii K, Tachibana T, Toda K, Horio T . Suppressed histamine release from rat peritoneal mast cells by ultraviolet B irradiation: decreased diacylglycerol formation as a possible mechanism. J Invest Dermatol. 1988; 90(6):806-9. DOI: 10.1111/1523-1747.ep12462027. View

11.

IKAI K, Danno K, Horio T, Narumiya S . Effect of ultraviolet irradiation on mast cell-deficient W/Wv mice. J Invest Dermatol. 1985; 85(1):82-4. DOI: 10.1111/1523-1747.ep12275365. View

12.

Okamoto H, Takigawa M, Horio T . Alteration of lymphocyte functions by 8-methoxypsoralen and longwave ultraviolet radiation. I. Suppressive effects of PUVA on T-lymphocyte migration in vitro. J Invest Dermatol. 1985; 84(3):203-5. DOI: 10.1111/1523-1747.ep12265126. View

13.

Doherty N, BEAVER T, Rheins L, Nordlund J . Multiple topical applications of arachidonic acid to mouse ears induce inflammatory and proliferative changes. J Invest Dermatol. 1988; 91(4):298-302. DOI: 10.1111/1523-1747.ep12475630. View

14.

Heiligstadt H, Kassis B, Weismann K, Sondergaad J . Prostaglandins in PUVA-treated psoriasis. Acta Derm Venereol. 1978; 58(3):213-6. View

15.

De Leo V, Horlick H, Hanson D, Eisinger M, Harber L . Ultraviolet radiation induces changes in membrane metabolism of human keratinocytes in culture. J Invest Dermatol. 1984; 83(5):323-6. DOI: 10.1111/1523-1747.ep12264114. View

16.

Okamoto H, Horio T . The effect of 8-methoxypsoralen and long-wave ultraviolet light on Langerhans cell. J Invest Dermatol. 1981; 77(4):345-6. DOI: 10.1111/1523-1747.ep12493242. View

17.

Langner A, Christophers E . Leukocyte chemotaxis after in vitro treatment with 8-methoxypsoralen and UVA. Arch Dermatol Res (1975). 1977; 260(1):51-5. DOI: 10.1007/BF00558014. View

18.

Burrall B, ZIBOH V . Increased biosynthesis of lipoxygenase products by UVB-irradiated guinea pig epidermis: evidence of a cyclooxygenase inhibitor. J Invest Dermatol. 1986; 86(6):643-8. DOI: 10.1111/1523-1747.ep12275653. View

19.

Danno K, Takigawa M, Horio T . The alterations of keratinocyte surface and basement membrane markers by treatment with 8-methoxypsoralen plus long-wave ultraviolet light. J Invest Dermatol. 1983; 80(3):172-4. DOI: 10.1111/1523-1747.ep12533415. View