Degradation of IgA Proteins by Pseudomonas Aeruginosa Elastase

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 1990 Mar 15

PMID 2107256

Citations 27

Authors

L W Heck

P G ALARCON

R M Kulhavy

K Morihara

M W Russell

J F Mestecky

Affiliations

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Abstract

Human colostral IgA and myeloma proteins of both IgA1 and IgA2 subclasses were susceptible to cleavage by Pseudomonas aeruginosa elastase. Detailed analysis of the cleavage products of IgA myeloma proteins revealed complete degradation of Fab with no evidence of intact Fab fragments as intermediate cleavage products. In contrast, both IgA1 and IgA2 proteins were resistant to cleavage by alkaline protease from P. aeruginosa. The susceptibility of human IgA proteins to elastase suggests a mechanism by which P. aeruginosa might evade the potentially protective function of IgA by producing this enzyme.

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