Interaction of ACTH, Corticosterone and Cyclic Nucleotides in Harding-Passey Melanoma Melanogenesis

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 1978 May 31

PMID 210723

Citations 1

Authors

J Abramowitz

W CHAVIN

Affiliations

Soon will be listed here.

Abstract

The acute in vitro action of adrenocorticotropin (ACTH) and corticosterone alone and in combination were determined in the Harding-Passey (HP) melanoma grown in vivo. Hormone treated melanoma dice (5--240 min) were analyzed for tyrosinase activity, cyclic AMP (cAMP) and cyclic GMP (cGMP). ACTH elevated cAMP and cGMP levels 20- and 13-fold, respectively, in the HP melanoma. However, these large increases in cyclic nucleotide levels were accompanied by only a 49% increase in tyrosinase activity. Corticosterone elicited a similar response. ACTH plus corticosterone produced an early cAMP and cGMP peak followed by depression. ACTH plus corticosterone stimulated tyrosinase activity coincident with the early cyclic nucleotide peak followed by a drop in tyrosinase activity which was subsequently elevated. The results indicate that neither cAMP nor cGMP are the sole modulators of tyrosinase activity and suggest the interaction of ACTH, corticosterone and cyclic nucleotides in the regulation of melanoma tyrosinase activity.

Citing Articles

Effect of ACTH and corticosterone on melanogenesis and cyclic nucleotide levels in the B-16 melanoma.

Abramowitz J, CHAVIN W Arch Dermatol Res. 1979; 264(3):293-8.

PMID: 223504 DOI: 10.1007/BF00412656.

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