Pediatric Pharmacogenetic and Pharmacogenomic Studies: the Current State and Future Perspectives

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 2010 Nov 12

PMID 21069522

Citations 6

Authors

Roberta Russo

Mario Capasso

Paolo Paolucci

Achille Iolascon

Affiliations

Soon will be listed here.

Abstract

Genetic differences among individuals can explain some of the variability observed during drug treatment. Many studies have correlated the different pharmacological response to genetic variability, but most of them have been conducted on adult populations. Much less attention has been given to the pediatric population. Pediatric patients constitute a vulnerable group with regard to rational drug prescribing since they present differences arising from the various stages of development. However, only a few steps have been made in developmental pharmacogenomics. This review attempts to describe the current methods for pharmacogenetic and pharmacogenomic studies, providing some of the most studied examples in pediatric patients. It also gives an overview on the implication and importance of microRNA polymorphisms, transcriptomics, metabonomics, and proteomics in pharmacogenetics and pharmacogenomics studies.

Citing Articles

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Getahun K, Angaw D, Asres M, Kahaliw W, Petros Z, Abay S Pharmgenomics Pers Med. 2024; 17:347-361.

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The Investigational Clinical Center: a clinical-supportive and patient-centered trial unit model. Ten years of experience through normal and pandemic times of a large pediatric trial center in Italy.

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