» Articles » PMID: 21069342

Signal Intensity in T2' Magnetic Resonance Imaging is Related to Brain Glioma Grade

Overview
Journal Eur Radiol
Specialty Radiology
Date 2010 Nov 12
PMID 21069342
Citations 13
Authors
Affiliations
Soon will be listed here.
Abstract

Objectives: T2' values reflect the presence of deoxyhaemoglobin related to high local oxygen extraction. We assessed the feasibility of T2' imaging to display regions with high metabolic activity in brain gliomas.

Methods: MRI was performed in 25 patients (12 female; median age 46 years; range 2-69) with brain gliomas with additional T2 and T2* sequences. T2' maps were derived from T2 and T2*. Dynamic susceptibility weighted contrast (DSC) perfusion was performed in 12/25 patients. Images were visually assessed by two readers and five ROIs were evaluated for each patient. Pearson correlation, Mann-Whitney and Kruskal-Wallis tests were applied for statistical analysis.

Results: Three patients were not further evaluated because of artefacts. Mean values of high-grade (III-IV) gliomas showed significantly lower T2' values than low-grade (II) gliomas (p < 0.001). An inverse relationship was observed between rCBV and sqr (T2') (r = -0.463, p < 0.001). No correlation was observed between T2' and rCBV for grade II tumours (r = 0.038; p = 0.875).

Conclusions: High-grade tumours revealed lower T2' values, presumably because of higher oxygen consumption in proliferating tissue. Our results indicate that T2' imaging can be used as an alternative to DSC perfusion in the detection of subtle deviations in tumour metabolism.

Citing Articles

Radiomic profiling for insular diffuse glioma stratification with distinct biologic pathway activities.

Duan W, Wang Z, Ma Z, Zheng H, Li Y, Pei D Cancer Sci. 2024; 115(4):1261-1272.

PMID: 38279197 PMC: 11007007. DOI: 10.1111/cas.16089.


Joint radial trajectory correction for accelerated T mapping on an MR-Linac.

Bano W, Holmes W, Goodburn R, Golbabaee M, Gupta A, Withey S Med Phys. 2023; 50(11):7027-7038.

PMID: 37245075 PMC: 10946747. DOI: 10.1002/mp.16479.


Magnetic resonance relaxometry in quantitative imaging of brain gliomas: A literature review.

Chekhonin I, Cohen O, Otazo R, Young R, Holodny A, Pronin I Neuroradiol J. 2023; 37(3):267-275.

PMID: 37133228 PMC: 11138331. DOI: 10.1177/19714009231173100.


Cerebral oxygen extraction fraction MRI: Techniques and applications.

Jiang D, Lu H Magn Reson Med. 2022; 88(2):575-600.

PMID: 35510696 PMC: 9233013. DOI: 10.1002/mrm.29272.


Quantitative MRI for analysis of peritumoral edema in malignant gliomas.

Blystad I, Warntjes J, Smedby O, Lundberg P, Larsson E, Tisell A PLoS One. 2017; 12(5):e0177135.

PMID: 28542553 PMC: 5441583. DOI: 10.1371/journal.pone.0177135.


References
1.
Law M, Yang S, Babb J, Knopp E, Golfinos J, Zagzag D . Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade. AJNR Am J Neuroradiol. 2004; 25(5):746-55. PMC: 7974484. View

2.
Adamson A, Rand S, Prost R, Kim T, Schultz C, Haughton V . Focal brain lesions: effect of single-voxel proton MR spectroscopic findings on treatment decisions. Radiology. 1998; 209(1):73-8. DOI: 10.1148/radiology.209.1.9769815. View

3.
Tamiya T, Kinoshita K, Ono Y, Matsumoto K, Furuta T, Ohmoto T . Proton magnetic resonance spectroscopy reflects cellular proliferative activity in astrocytomas. Neuroradiology. 2000; 42(5):333-8. DOI: 10.1007/s002340050894. View

4.
Cha S, Knopp E, Johnson G, Wetzel S, Litt A, Zagzag D . Intracranial mass lesions: dynamic contrast-enhanced susceptibility-weighted echo-planar perfusion MR imaging. Radiology. 2002; 223(1):11-29. DOI: 10.1148/radiol.2231010594. View

5.
Hakyemez B, Erdogan C, Bolca N, Yildirim N, Gokalp G, Parlak M . Evaluation of different cerebral mass lesions by perfusion-weighted MR imaging. J Magn Reson Imaging. 2006; 24(4):817-24. DOI: 10.1002/jmri.20707. View