Thalamus Abnormalities During Working Memory in Schizophrenia. An FMRI Study

Overview

Journal Schizophr Res

Specialty Psychiatry

Date 2010 Nov 12

PMID 21067898

Citations 16

Authors

Julie Bor

Jerome Brunelin

Dominique Sappey-Marinier

Danielle Ibarrola

Thierry DAmato

Marie-Francoise Suaud-Chagny

Mohamed Saoud

Affiliations

Soon will be listed here.

Abstract

We aimed to identify and compare cerebral activations in schizophrenia patients and controls during a working memory (WM) task at the same performance level for both a verbal and a spatial task. Whereas the performances of the patients (n=22) and controls (n=15) were similar, cerebral activations were significantly increased in the patients, particularly in the thalamus/basal ganglia for the two tasks and in regions of the prefrontal cortex and the cerebellum for the spatial task only. Our results suggest that stronger activations of deep brain structures in patients may be the result from a compensating mechanism for WM difficulties.

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