Sry: the Master Switch in Mammalian Sex Determination

Overview

Journal Development

Specialty Biology

Date 2010 Nov 11

PMID 21062860

Citations 152

Authors

Kenichi Kashimada

Peter Koopman

Affiliations

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Abstract

SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which in turn drives testis formation. Here, we discuss the cascade of events triggered by SRY and the mechanisms that reinforce the differentiation of the testes in males while actively inhibiting ovarian development.

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