Calcium Dynamics and Signaling in Vascular Regulation: Computational Models

Overview

Journal Wiley Interdiscip Rev Syst Biol Med

Specialties Biology
General Medicine
Medical Informatics

Date 2010 Nov 10

PMID 21061306

Citations 9

Authors

Nikolaos Michael Tsoukias

Affiliations

Soon will be listed here.

Abstract

Calcium is a universal signaling molecule with a central role in a number of vascular functions including in the regulation of tone and blood flow. Experimentation has provided insights into signaling pathways that lead to or affected by Ca(2+) mobilization in the vasculature. Mathematical modeling offers a systematic approach to the analysis of these mechanisms and can serve as a tool for data interpretation and for guiding new experimental studies. Comprehensive models of calcium dynamics are well advanced for some systems such as the heart. This review summarizes the progress that has been made in modeling Ca(2+) dynamics and signaling in vascular cells. Model simulations show how Ca(2+) signaling emerges as a result of complex, nonlinear interactions that cannot be properly analyzed using only a reductionist's approach. A strategy of integrative modeling in the vasculature is outlined that will allow linking macroscale pathophysiological responses to the underlying cellular mechanisms.

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References

De Young G, Keizer J . A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration. Proc Natl Acad Sci U S A. 1992; 89(20):9895-9. PMC: 50240. DOI: 10.1073/pnas.89.20.9895. View

Hill A, Hinton J, Cheng H, Gao Z, Bates D, Hancox J . A TRPC-like non-selective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells. Cell Calcium. 2006; 40(1):29-40. DOI: 10.1016/j.ceca.2006.03.007. View

Fink C, Slepchenko B, Loew L . Determination of time-dependent inositol-1,4,5-trisphosphate concentrations during calcium release in a smooth muscle cell. Biophys J. 1999; 77(1):617-28. PMC: 1300358. DOI: 10.1016/S0006-3495(99)76918-3. View

Golovina V, Blaustein M . Spatially and functionally distinct Ca2+ stores in sarcoplasmic and endoplasmic reticulum. Science. 1997; 275(5306):1643-8. DOI: 10.1126/science.275.5306.1643. View

Silva J, Pan H, Wu D, Nekouzadeh A, Decker K, Cui J . A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential. Proc Natl Acad Sci U S A. 2009; 106(27):11102-6. PMC: 2700153. DOI: 10.1073/pnas.0904505106. View

Sonkusare S, Palade P, Marsh J, Telemaque S, Pesic A, Rusch N . Vascular calcium channels and high blood pressure: pathophysiology and therapeutic implications. Vascul Pharmacol. 2006; 44(3):131-42. PMC: 4917380. DOI: 10.1016/j.vph.2005.10.005. View

Blaustein M, Zhang J, Chen L, Song H, Raina H, Kinsey S . The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension. Hypertension. 2008; 53(2):291-8. PMC: 2727927. DOI: 10.1161/HYPERTENSIONAHA.108.119974. View

Tallini Y, Brekke J, Shui B, Doran R, Hwang S, Nakai J . Propagated endothelial Ca2+ waves and arteriolar dilation in vivo: measurements in Cx40BAC GCaMP2 transgenic mice. Circ Res. 2007; 101(12):1300-9. DOI: 10.1161/CIRCRESAHA.107.149484. View

Tsoukias N, Kavdia M, Popel A . A theoretical model of nitric oxide transport in arterioles: frequency- vs. amplitude-dependent control of cGMP formation. Am J Physiol Heart Circ Physiol. 2003; 286(3):H1043-56. DOI: 10.1152/ajpheart.00525.2003. View

10.

Aalkjaer C, Nilsson H . Vasomotion: cellular background for the oscillator and for the synchronization of smooth muscle cells. Br J Pharmacol. 2005; 144(5):605-16. PMC: 1576043. DOI: 10.1038/sj.bjp.0706084. View

11.

Yang J, Clark Jr J, Bryan R, Robertson C . The myogenic response in isolated rat cerebrovascular arteries: smooth muscle cell model. Med Eng Phys. 2003; 25(8):691-709. DOI: 10.1016/s1350-4533(03)00100-0. View

12.

Wong A, KLASSEN G . A model of electrical activity and cytosolic calcium dynamics in vascular endothelial cells in response to fluid shear stress. Ann Biomed Eng. 1995; 23(6):822-32. DOI: 10.1007/BF02584481. View

13.

Koenigsberger M, Sauser R, Beny J, Meister J . Role of the endothelium on arterial vasomotion. Biophys J. 2005; 88(6):3845-54. PMC: 1305618. DOI: 10.1529/biophysj.104.054965. View

14.

Parthimos D, Edwards D, Griffith T . Minimal model of arterial chaos generated by coupled intracellular and membrane Ca2+ oscillators. Am J Physiol. 1999; 277(3):H1119-44. DOI: 10.1152/ajpheart.1999.277.3.H1119. View

15.

Vu T, Hung D, Wheaton V, Coughlin S . Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991; 64(6):1057-68. DOI: 10.1016/0092-8674(91)90261-v. View

16.

Figueroa X, Chen C, Campbell K, Damon D, Day K, Ramos S . Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?. Am J Physiol Heart Circ Physiol. 2007; 293(3):H1371-83. DOI: 10.1152/ajpheart.01368.2006. View

17.

R Shannon T, Wang F, Puglisi J, Weber C, Bers D . A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J. 2004; 87(5):3351-71. PMC: 1304803. DOI: 10.1529/biophysj.104.047449. View

18.

Nilius B, Viana F, Droogmans G . Ion channels in vascular endothelium. Annu Rev Physiol. 1997; 59:145-70. DOI: 10.1146/annurev.physiol.59.1.145. View

19.

Sandow S, Neylon C, Chen M, Garland C . Spatial separation of endothelial small- and intermediate-conductance calcium-activated potassium channels (K(Ca)) and connexins: possible relationship to vasodilator function?. J Anat. 2006; 209(5):689-98. PMC: 2100349. DOI: 10.1111/j.1469-7580.2006.00647.x. View

20.

Kapela A, Tsoukias N, Bezerianos A . New aspects of vulnerability in heterogeneous models of ventricular wall and its modulation by loss of cardiac sodium channel function. Med Biol Eng Comput. 2005; 43(3):387-94. DOI: 10.1007/BF02345817. View