Gene Expression Profile in Rat Dorsal Root Ganglion Following Sciatic Nerve Injury and Systemic Neurotrophin-3 Administration

Overview

Journal J Mol Neurosci

Specialties Molecular Biology
Neurology

Date 2010 Nov 10

PMID 21061088

Citations 6

Authors

Lu-Ting Kuo

Shao-Yu Tsai

Michael J Groves

Shu F An

Francesco Scaravilli

Affiliations

Soon will be listed here.

Abstract

Following sciatic nerve transection in adult rats, a proportion of injured dorsal root ganglion (DRG) neurons die, through apoptosis, over the following 6 months. Previous studies showed that axotomy and neurotrophin-3 administration may have effects on expression of neurotrophins and their receptors in DRG. In the current study, the fourth and fifth lumbar DRGs of rats were examined 2 weeks after right sciatic nerve transection and ligation. The effects of axotomy and systemic NT-3 treatment on neuronal genes were investigated by microarray. The results demonstrated that bone morphogenetic protein (BMP) and Janus protein tyrosine kinase signaling pathways are induced in axotomized DRG, and PI-3 kinase and BMP pathways and genes controlling various cellular functions were induced after axotomy and NT-3 administration.

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