A Huge Renal Cell Carcinoma, Nine Years After Its Primary Diagnosis and Obligate Observation

Overview

Journal Case Rep Oncol

Publisher Karger

Specialty Oncology

Date 2010 Nov 10

PMID 21060769

Citations 5

Authors

Mohammad Kazem Moslemi

Seiied Jalal Esshagh Hosseini

Mohammad Hasan Dehghani Firoozabadi

Affiliations

Soon will be listed here.

Abstract

The clinical diagnosis of renal cell carcinoma (RCC) is radiographic. Effective imaging of the kidneys can be achieved by ultrasound, CT or MRI [Chawla et al.: J Urol 2006;175:425-431]. Solid lesions detected by ultrasound and those showing enhancement on cross-sectional imaging are considered malignant until proven otherwise. The standard of care for clinically localized RCC remains surgical resection due to the favorable prognosis associated with surgery and the relative ineffectiveness of systemic therapy. Since patients with localized RCC are often symptom-free, they sometimes refuse to receive surgical treatment or are left untreated based on a diagnosis of benign lesions. There are also cases where an RCC is relatively large and causes symptoms but is not treated surgically because of complications and other reasons. We report a 54-year-old male who underwent a difficult radical nephrectomy 9 years after the primary RCC malignancy diagnosis.

Citing Articles

Radical nephrectomy for a giant chromophobe renal cell carcinoma diagnosed > 17 years previously: a case report and literature review.

Lan J, Lan D, Yuan W, Ying Q, He J, Gu Y Front Oncol. 2024; 14:1352689.

PMID: 38634044 PMC: 11021568. DOI: 10.3389/fonc.2024.1352689.

Syncope as the Initial Manifestation of a Late-Stage Renal Cell Carcinoma With Metastasis to the Brain.

Ying G, Jeelani H, Chaney M, Piao X, Jain N, Shayuk M Cureus. 2021; 13(7):e16185.

PMID: 34367792 PMC: 8335967. DOI: 10.7759/cureus.16185.

A case of the world's largest renal cell carcinoma.

Takeda K, Murray G, Vohra N, Fallon J IJU Case Rep. 2021; 4(1):49-52.

PMID: 33426498 PMC: 7784761. DOI: 10.1002/iju5.12236.

Prolonged natural history of a cystic renal cell carcinoma: A case report.

Gupta M, Kaundal P, Bora G, Gorsi U, Mavuduru R Indian J Urol. 2020; 36(4):315-317.

PMID: 33376271 PMC: 7759162. DOI: 10.4103/iju.IJU_177_20.

A Case Report of Largest Documented Multilocular Cystic Nephroma Removed by Thoracoabdominal Approach.

Sawant A, Savalia A, Pawar P, Narwade S, Chaudhari R J Clin Diagn Res. 2017; 11(7):PD10-PD12.

PMID: 28892971 PMC: 5583937. DOI: 10.7860/JCDR/2017/25612.10244.

References

Frank I, Blute M, Leibovich B, Cheville J, Lohse C, Zincke H . Independent validation of the 2002 American Joint Committee on cancer primary tumor classification for renal cell carcinoma using a large, single institution cohort. J Urol. 2005; 173(6):1889-92. DOI: 10.1097/01.ju.0000158043.94525.d6. View

Klatte T, Patard J, de Martino M, Bensalah K, Verhoest G, De La Taille A . Tumor size does not predict risk of metastatic disease or prognosis of small renal cell carcinomas. J Urol. 2008; 179(5):1719-26. DOI: 10.1016/j.juro.2008.01.018. View

Youssif T, Kassouf W, Steinberg J, Aprikian A, Laplante M, Tanguay S . Active surveillance for selected patients with renal masses: updated results with long-term follow-up. Cancer. 2007; 110(5):1010-4. DOI: 10.1002/cncr.22871. View

Chawla S, Crispen P, Hanlon A, Greenberg R, Chen D, Uzzo R . The natural history of observed enhancing renal masses: meta-analysis and review of the world literature. J Urol. 2006; 175(2):425-31. DOI: 10.1016/S0022-5347(05)00148-5. View

Kunkle D, Crispen P, Chen D, Greenberg R, Uzzo R . Enhancing renal masses with zero net growth during active surveillance. J Urol. 2007; 177(3):849-53. DOI: 10.1016/j.juro.2006.10.073. View

Clark J, Atkins M, Urba W, Creech S, Figlin R, Dutcher J . Adjuvant high-dose bolus interleukin-2 for patients with high-risk renal cell carcinoma: a cytokine working group randomized trial. J Clin Oncol. 2003; 21(16):3133-40. DOI: 10.1200/JCO.2003.02.014. View

Kouba E, Smith A, McRackan D, Wallen E, Pruthi R . Watchful waiting for solid renal masses: insight into the natural history and results of delayed intervention. J Urol. 2007; 177(2):466-70. DOI: 10.1016/j.juro.2006.09.064. View

Chow W, Devesa S, Warren J, Fraumeni Jr J . Rising incidence of renal cell cancer in the United States. JAMA. 1999; 281(17):1628-31. DOI: 10.1001/jama.281.17.1628. View

Rendon R, Stanietzky N, Panzarella T, Robinette M, Klotz L, Thurston W . The natural history of small renal masses. J Urol. 2000; 164(4):1143-7. View

10.

Nuttall M, Cathcart P, van der Meulen J, Gillatt D, McIntosh G, Emberton M . A description of radical nephrectomy practice and outcomes in England: 1995-2002. BJU Int. 2005; 96(1):58-61. DOI: 10.1111/j.1464-410X.2005.05567.x. View

11.

Lamb G, Bromwich E, Vasey P, Aitchison M . Management of renal masses in patients medically unsuitable for nephrectomy--natural history, complications, and outcome. Urology. 2004; 64(5):909-13. DOI: 10.1016/j.urology.2004.05.039. View

12.

Kato M, Suzuki T, Suzuki Y, Terasawa Y, Sasano H, Arai Y . Natural history of small renal cell carcinoma: evaluation of growth rate, histological grade, cell proliferation and apoptosis. J Urol. 2004; 172(3):863-6. DOI: 10.1097/01.ju.0000136315.80057.99. View

13.

Fujimoto N, Sugita A, Terasawa Y, Kato M . Observations on the growth rate of renal cell carcinoma. Int J Urol. 1995; 2(2):71-6. DOI: 10.1111/j.1442-2042.1995.tb00427.x. View

14.

Hock L, Lynch J, Balaji K . Increasing incidence of all stages of kidney cancer in the last 2 decades in the United States: an analysis of surveillance, epidemiology and end results program data. J Urol. 2001; 167(1):57-60. View

15.

Negrier S, Escudier B, Lasset C, Douillard J, Savary J, Chevreau C . Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Français d'Immunothérapie. N Engl J Med. 1998; 338(18):1272-8. DOI: 10.1056/NEJM199804303381805. View

16.

Crispen P, Viterbo R, Fox E, Greenberg R, Chen D, Uzzo R . Delayed intervention of sporadic renal masses undergoing active surveillance. Cancer. 2008; 112(5):1051-7. DOI: 10.1002/cncr.23268. View

17.

Hollingsworth J, Miller D, Daignault S, Hollenbeck B . Rising incidence of small renal masses: a need to reassess treatment effect. J Natl Cancer Inst. 2006; 98(18):1331-4. DOI: 10.1093/jnci/djj362. View

18.

Volpe A, Panzarella T, Rendon R, Haider M, Kondylis F, Jewett M . The natural history of incidentally detected small renal masses. Cancer. 2004; 100(4):738-45. DOI: 10.1002/cncr.20025. View