Tandem Facial Amphiphiles for Membrane Protein Stabilization

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2010 Nov 6

PMID 21049926

Citations 37

Authors

Pil Seok Chae

Kamil Gotfryd

Jennifer Pacyna

Larry J W Miercke

Soren G F Rasmussen

Rebecca A Robbins

Rohini R Rana

Claus J Loland

Brian Kobilka

Robert Stroud

Bernadette Byrne

Ulrik Gether

Samuel H Gellman

Affiliations

Soon will be listed here.

Abstract

We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.

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