Common SNPs in Myelin Transcription Factor 1-like (MYT1L): Association with Major Depressive Disorder in the Chinese Han Population

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2010 Nov 5

PMID 21048971

Citations 12

Authors

Ti Wang

Zhen Zeng

Tao Li

Jie Liu

Junyan Li

You Li

Qian Zhao

Zhiyun Wei

Yang Wang

Baojie Li

Guoyin Feng

Lin He

Yongyong Shi

Affiliations

Soon will be listed here.

Abstract

Background: Myelin transcription factor 1-like (MYT1L) is a member of the myelin transcription factor 1 (MYT1) gene family, and the neural specific, zinc-finger-containing, DNA-binding protein that it encodes plays a role in the development of the nervous system. On the basis of a recent copy number variation (CNV) study showing that this gene is disrupted in mental disorder patients, we investigated whether MYT1L also plays a role in MDD.

Methods: In this study, 8 SNPs were analyzed in 1139 MDD patients and 1140 controls of Chinese Han origin.

Results: Statistically significant differences were noted between cases and controls for rs3748989 (allele: permutated p = 0.0079, corrected p = 0.0048, genotype: corrected p = 0.0204). A haplotype of rs1617213 and rs6759709 G-C was also significant (permutated p = 0.00007).

Conclusion: Our results indicate that MYT1L may be a potential risk gene for MDD in the Chinese Han population.

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