Genetic Mapping and Developmental Timing of Transmission Ratio Distortion in a Mouse Interspecific Backcross

Overview

Journal BMC Genet

Publisher Biomed Central

Specialties Biotechnology
Molecular Biology

Date 2010 Nov 4

PMID 21044349

Citations 9

Authors

Chevonne D Eversley

Tavia Clark

Yuying Xie

Jill Steigerwalt

Timothy A Bell

Fernando P M de Villena

David W Threadgill

Affiliations

Soon will be listed here.

Abstract

Background: Transmission ratio distortion (TRD), defined as statistically significant deviation from expected 1:1 Mendelian ratios of allele inheritance, results in a reduction of the expected progeny of a given genotype. Since TRD is a common occurrence within interspecific crosses, a mouse interspecific backcross was used to genetically map regions showing TRD, and a developmental analysis was performed to identify the timing of allele loss.

Results: Three independent events of statistically significant deviation from the expected 50:50 Mendelian inheritance ratios were observed in an interspecific backcross between the Mus musculus A/J and the Mus spretus SPRET/EiJ inbred strains. At weaning M. musculus alleles are preferentially inherited on Chromosome (Chr) 7, while M. spretus alleles are preferentially inherited on Chrs 10 and 11. Furthermore, alleles on Chr 3 modify the TRD on Chr 11. All TRD loci detected at weaning were present in Mendelian ratios at mid-gestation and at birth.

Conclusions: Given that Mendelian ratios of inheritance are observed for Chr 7, 10 and 11 during development and at birth, the underlying causes for the interspecific TRD events are the differential post-natal survival of pups with specific genotypes. These results are consistent with the TRD mechanism being deviation from Mendelian inheritance rather than meiotic drive or segregation distortion.

Citing Articles

A method for low-coverage single-gamete sequence analysis demonstrates adherence to Mendel's first law across a large sample of human sperm.

Carioscia S, Weaver K, Bortvin A, Pan H, Ariad D, Bell A Elife. 2022; 11.

PMID: 36475543 PMC: 9844984. DOI: 10.7554/eLife.76383.

Non-Mendelian segregation and transmission drive of B chromosomes.

Camacho J Chromosome Res. 2022; 30(2-3):217-228.

PMID: 35657532 DOI: 10.1007/s10577-022-09692-7.

Maternal Transmission Ratio Distortion in Two Iberian Pig Varieties.

Vazquez-Gomez M, Hijas-Villalba M, Varona L, Ibanez-Escriche N, Rosas J, Negro S Genes (Basel). 2020; 11(9).

PMID: 32899475 PMC: 7563664. DOI: 10.3390/genes11091050.

Identification and Characterization of Segregation Distortion Loci on Cotton Chromosome 18.

Dai B, Guo H, Huang C, Ahmed M, Lin Z Front Plant Sci. 2017; 7:2037.

PMID: 28149299 PMC: 5242213. DOI: 10.3389/fpls.2016.02037.

R2d2 Drives Selfish Sweeps in the House Mouse.

Didion J, Morgan A, Yadgary L, Bell T, McMullan R, Ortiz de Solorzano L Mol Biol Evol. 2016; 33(6):1381-95.

PMID: 26882987 PMC: 4868115. DOI: 10.1093/molbev/msw036.

References

Biddle F . Segregation distortion of X-linked marker genes in interspecific crosses between Mus musculus and M. spretus. Genome. 1987; 29(2):389-92. DOI: 10.1139/g87-067. View

Chevin L, Hospital F . The hitchhiking effect of an autosomal meiotic drive gene. Genetics. 2006; 173(3):1829-32. PMC: 1526655. DOI: 10.1534/genetics.105.052977. View

Slamka C, Fonseca M, Naumova A, Paquette J, Pannunzio P, Smith M . Transmission-ratio distortion through F1 females at chromosome 11 loci linked to Om in the mouse DDK syndrome. Genetics. 1996; 142(4):1299-304. PMC: 1207126. DOI: 10.1093/genetics/142.4.1299. View

Guenet J, Simon-Chazottes D, Avner P . The use of interspecific mouse crosses for gene localization: present status and future perspectives. Curr Top Microbiol Immunol. 1988; 137:13-7. DOI: 10.1007/978-3-642-50059-6_2. View

Siracusa L, Alvord W, Bickmore W, Jenkins N, Copeland N . Interspecific backcross mice show sex-specific differences in allelic inheritance. Genetics. 1991; 128(4):813-21. PMC: 1204554. DOI: 10.1093/genetics/128.4.813. View

Gaultier C, Gallego J . Neural control of breathing: insights from genetic mouse models. J Appl Physiol (1985). 2008; 104(5):1522-30. DOI: 10.1152/japplphysiol.01266.2007. View

Yang H, Bell T, Churchill G, Pardo-Manuel de Villena F . On the subspecific origin of the laboratory mouse. Nat Genet. 2007; 39(9):1100-7. DOI: 10.1038/ng2087. View

Ceci J, Siracusa L, Jenkins N, Copeland N . A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes. Genomics. 1989; 5(4):699-709. DOI: 10.1016/0888-7543(89)90111-0. View

Bell T, de la Casa-Esperon E, Doherty H, Ideraabdullah F, Kim K, Wang Y . The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11. Genetics. 2005; 172(1):411-23. PMC: 1456169. DOI: 10.1534/genetics.105.047118. View

10.

Horsthemke B, Wagstaff J . Mechanisms of imprinting of the Prader-Willi/Angelman region. Am J Med Genet A. 2008; 146A(16):2041-52. DOI: 10.1002/ajmg.a.32364. View

11.

Silver L . The peculiar journey of a selfish chromosome: mouse t haplotypes and meiotic drive. Trends Genet. 1993; 9(7):250-4. DOI: 10.1016/0168-9525(93)90090-5. View

12.

Van Boven M, Weissing F . Competition at the mouse t complex: rare alleles are inherently favored. Theor Popul Biol. 2002; 60(4):343-58. DOI: 10.1006/tpbi.2001.1551. View

13.

Guenet J, Bonhomme F . Wild mice: an ever-increasing contribution to a popular mammalian model. Trends Genet. 2002; 19(1):24-31. DOI: 10.1016/s0168-9525(02)00007-0. View

14.

Rowe L, Nadeau J, Turner R, Frankel W, Letts V, Eppig J . Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm Genome. 1994; 5(5):253-74. DOI: 10.1007/BF00389540. View

15.

Duselis A, Wiley C, ONeill M, Vrana P . Genetic evidence for a maternal effect locus controlling genomic imprinting and growth. Genesis. 2005; 43(4):155-65. DOI: 10.1002/gene.20166. View

16.

Pardo-Manuel de Villena F, de la Casa-Esperon E, Briscoe T, Sapienza C . A genetic test to determine the origin of maternal transmission ratio distortion. Meiotic drive at the mouse Om locus. Genetics. 2000; 154(1):333-42. PMC: 1460926. DOI: 10.1093/genetics/154.1.333. View

17.

Siracusa L, Buchberg A, Copeland N, Jenkins N . Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus. Genetics. 1989; 122(3):669-79. PMC: 1203740. DOI: 10.1093/genetics/122.3.669. View

18.

Lyon M, Meredith R . INVESTIGATIONS OF THE NATURE OF T-ALLELES IN THE MOUSE. I. GENETIC ANALYSIS OF A SERIES OF MUTANTS DERIVED FROM A LETHAL ALLELE. Heredity (Edinb). 1964; 19:301-12. DOI: 10.1038/hdy.1964.33. View

19.

Roberts A, Pardo-Manuel de Villena F, Wang W, McMillan L, Threadgill D . The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics. Mamm Genome. 2007; 18(6-7):473-81. PMC: 1998888. DOI: 10.1007/s00335-007-9045-1. View

20.

Vrana P, Matteson P, Schmidt J, Ingram R, Joyce A, Prince K . Genomic imprinting of a placental lactogen gene in Peromyscus. Dev Genes Evol. 2002; 211(11):523-32. DOI: 10.1007/s00427-001-0188-x. View