Concepts of Neuroendocrine Cardiology and Neuroendocrine Immunology, Chemistry and Biology of Signal Molecules

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2010 Nov 3

PMID 21042849

Citations 2

Authors

Armen Galoyan

Affiliations

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Abstract

Discovery of neurosecretion of cardioactive neurohormones produced by hypothalamic nuclei (NSO and NPV), as well as the biosynthesis of several immunomodulators (signal molecules of the neuroendocrine immune system of brain), deciphering of their chemical structure and study of their biological properties led to the foundation of two important trends of neurobiology: neuroendocrine immunology and cardiology. Hormone formation by atrium ganglionary nerve cells and auriculum establishment of neurohumoral interactions between hypothalamic and atrium neurosecretion indicated the existence of the system neuroendocrine hypothalamus--endocrine heart. Study of their biological properties promoted creation of powerful neurohormonal preparations for the treatment of immune, cardio-vascular, neurodegenerative, infectious and tumor diseases. Concepts suggested by us on neuroendocrine cardiology and immunology, create large perspectives for development of the theory and its implementation in medicine.

Citing Articles

Epigenetic control of cancer by neuropeptides.

Galoian K, Patel P Biomed Rep. 2017; 6(1):3-7.

PMID: 28123699 PMC: 5244791. DOI: 10.3892/br.2016.804.

The protective and immunomodulatory effects of hypothalamic proline-rich polypeptide galarmin against methicillin-resistant Staphylococcus aureus infection in mice.

Durgaryan A, Matevosyan M, Seferyan T, Sargsyan M, Grigoryan S, Galoian K Eur J Clin Microbiol Infect Dis. 2012; 31(9):2153-65.

PMID: 22322358 DOI: 10.1007/s10096-012-1550-9.

References

Galoyan A, Grigoryan S, Badalyan K . Treatment and prophylaxis of anthrax by new neurosecretory cytokines. Neurochem Res. 2006; 31(6):795-803. DOI: 10.1007/s11064-006-9082-2. View

Abrahamian S, Fodor M, Gorcs T, Galoyan A, Palkovits M . Neuropeptides in atrial subepicardial ganglia of rats. Acta Morphol Hung. 1991; 39(4):267-78. View

Galoyan A, Korochkin L, Rybalkina E, Pavlova G, Saburina I, Zaraiski E . Hypothalamic proline-rich polypeptide enhances bone marrow colony-forming cell proliferation and stromal progenitor cell differentiation. Cell Transplant. 2009; 17(9):1061-6. DOI: 10.3727/096368908786991579. View

Srapionian R, Mardanian S, Saakian S, Karapetian R, Saakian F . [Study of the conformation of neurospecific cardioactive glycoproteins by optical spectroscopy]. Biokhimiia. 1987; 52(1):89-95. View

Gurvits B, Tretyakov O, Klishina N, Stoeva S, Voelter W, Galoyan A . Identification of macrophage migration inhibitory factor isoforms in bovine brain. Neurochem Res. 2000; 25(8):1125-9. DOI: 10.1023/a:1007678214348. View

Guillemin R . Peptides in the brain: the new endocrinology of the neuron. Science. 1978; 202(4366):390-402. DOI: 10.1126/science.212832. View

de Bold A, Borenstein H, Veress A, Sonnenberg H . A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci. 1981; 28(1):89-94. DOI: 10.1016/0024-3205(81)90370-2. View

Wharton J, Gulbenkian S, Merighi A, Kuhn D, Jahn R, Taylor K . Immunohistochemical and ultrastructural localisation of peptide-containing nerves and myocardial cells in the human atrial appendage. Cell Tissue Res. 1988; 254(1):155-66. DOI: 10.1007/BF00220029. View

Barkhudaryan N, Oberthuer W, Lottspeich F, Galoyan A . Structure of hypothalamic coronaro-constrictory peptide factors. Neurochem Res. 1992; 17(12):1217-21. DOI: 10.1007/BF00968403. View

10.

Flynn T, Davies P . The biochemistry and molecular biology of atrial natriuretic factor. Biochem J. 1985; 232(2):313-21. PMC: 1152881. DOI: 10.1042/bj2320313. View

11.

Glembotski C, Wildey G, Gibson T . Molecular forms of immunoactive atrial natriuretic peptide in the rat hypothalamus and atrium. Biochem Biophys Res Commun. 1985; 129(3):671-8. DOI: 10.1016/0006-291x(85)91944-8. View

12.

de Bold A . Heart atria granularity effects of changes in water-electrolyte balance. Proc Soc Exp Biol Med. 1979; 161(4):508-11. DOI: 10.3181/00379727-161-40584. View

13.

Galoyan A, Gurvitis BYa , Shuvalova L, Davis M, Shively J, Lee T . A hypothalamic activator of calmodulin-dependent enzymes is thymosin beta 4 (1-39). Neurochem Res. 1992; 17(8):773-7. DOI: 10.1007/BF00969011. View

14.

Schally A, Coy D, Meyers C . Hypothalamic regulatory hormones. Annu Rev Biochem. 1978; 47:89-128. DOI: 10.1146/annurev.bi.47.070178.000513. View

15.

Galoyan A, Shakhlamov V, Aghajanov M, Vahradyan H . Hypothalamic proline-rich polypeptide protects brain neurons in aluminum neurotoxicosis. Neurochem Res. 2004; 29(7):1349-57. DOI: 10.1023/b:nere.0000026396.77459.1f. View

16.

Coggin M, Srapionian R, Brecher A, Galoyan A . Comparative effects of atrial polypeptide and neurohormone C on the interaction of factor Xa with antithrombin III. Blood Coagul Fibrinolysis. 2008; 19(7):645-51. DOI: 10.1097/MBC.0b013e328305094f. View

17.

Furukawa T, Sugita H, TOYOKURA Y . Comparative studies on myofibrillar proteins in different types of skeletal muscle fibers. Exp Neurol. 1972; 37(3):515-21. DOI: 10.1016/0014-4886(72)90095-7. View

18.

Galoyan A, Sarkissian J, Chavushyan V, Sulkhanyan R, Avakyan Z, Avetisyan Z . Neuroprotective action of hypothalamic peptide PRP-1 at various time survivals following spinal cord hemisection. Neurochem Res. 2005; 30(4):507-25. DOI: 10.1007/s11064-005-2686-0. View

19.

NEEDLEMAN P, Adams S, Cole B, Currie M, GELLER D, Michener M . Atriopeptins as cardiac hormones. Hypertension. 1985; 7(4):469-82. DOI: 10.1161/01.hyp.7.4.469. View

20.

Gill G, GARREN L . A cyclic-3',5'-adenosine monophosphate dependent protein kinase from the adrenal cortex: comparison with a cyclic AMP binding protein. Biochem Biophys Res Commun. 1970; 39(3):335-43. DOI: 10.1016/0006-291x(70)90581-4. View