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Therapy: Gut-mediated Autoimmune Arthritis Treated with Antibiotics

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Specialty Rheumatology
Date 2010 Nov 2
PMID 21037561
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Abstract

Bacterial infection is known to trigger a number of autoimmune disorders, an observation that indicates a potentially important role for antibiotics in treating these diseases. Indeed, results from an experimental model of autoimmune arthritis in mice suggest that antibiotics can prevent the onset of disease.

References
1.
Robertson K, Volmink J, Mayosi B . Antibiotics for the primary prevention of acute rheumatic fever: a meta-analysis. BMC Cardiovasc Disord. 2005; 5(1):11. PMC: 1164408. DOI: 10.1186/1471-2261-5-11. View

2.
Kouskoff V, Korganow A, Duchatelle V, Degott C, Benoist C, Mathis D . Organ-specific disease provoked by systemic autoimmunity. Cell. 1996; 87(5):811-22. DOI: 10.1016/s0092-8674(00)81989-3. View

3.
Schlosstein L, Terasaki P, Bluestone R, Pearson C . High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med. 1973; 288(14):704-6. DOI: 10.1056/NEJM197304052881403. View

4.
Stone M, Fortin P, Pacheco-Tena C, Inman R . Should tetracycline treatment be used more extensively for rheumatoid arthritis? Metaanalysis demonstrates clinical benefit with reduction in disease activity. J Rheumatol. 2003; 30(10):2112-22. View

5.
Wallin J, Hillert J, Olerup O, Carlsson B, Strom H . Association of rheumatoid arthritis with a dominant DR1/Dw4/Dw14 sequence motif, but not with T cell receptor beta chain gene alleles or haplotypes. Arthritis Rheum. 1991; 34(11):1416-24. DOI: 10.1002/art.1780341112. View