Investigation of the Influence of EPs® 7630, a Herbal Drug Preparation from Pelargonium Sidoides, on Replication of a Broad Panel of Respiratory Viruses

Overview

Journal Phytomedicine

Specialty Rehabilitation Medicine

Date 2010 Nov 2

PMID 21036571

Citations 61

Authors

Martin Michaelis

Hans Wilhelm Doerr

Jindrich Cinatl Jr

Affiliations

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Abstract

The Pelargonium sidoides extract EPs® 7630 is an approved drug for the treatment of acute bronchitis in Germany. The postulated mechanisms underlying beneficial effects of EPs® 7630 in bronchitis patients include immunomodulatory and cytoprotective effects, inhibition of interaction between bacteria and host cells, and increase of cilliary beat frequency on respiratory cells. Here, we investigated the influence of EPs® 7630 on replication of a panel of respiratory viruses. Determination of virus-induced cytopathogenic effects and virus titres revealed that EPs® 7630 at concentrations up to 100 μg/ml interfered with replication of seasonal influenza A virus strains (H1N1, H3N2), respiratory syncytial virus, human coronavirus, parainfluenza virus, and coxsackie virus but did not affect replication of highly pathogenic avian influenza A virus (H5N1), adenovirus, or rhinovirus. Therefore, antiviral effects may contribute to the beneficial effects exerted by EPs® 7630 in acute bronchitis patients.

Citing Articles

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Multiple mechanisms enable broad-spectrum activity of the root extract EPs 7630 against acute respiratory tract infections.

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