Stem Cell-based Biological Tooth Repair and Regeneration

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2010 Nov 2

PMID 21035344

Citations 100

Authors

Ana Angelova Volponi

Yvonne Pang

Paul T Sharpe

Affiliations

Soon will be listed here.

Abstract

Teeth exhibit limited repair in response to damage, and dental pulp stem cells probably provide a source of cells to replace those damaged and to facilitate repair. Stem cells in other parts of the tooth, such as the periodontal ligament and growing roots, play more dynamic roles in tooth function and development. Dental stem cells can be obtained with ease, making them an attractive source of autologous stem cells for use in restoring vital pulp tissue removed because of infection, in regeneration of periodontal ligament lost in periodontal disease, and for generation of complete or partial tooth structures to form biological implants. As dental stem cells share properties with mesenchymal stem cells, there is also considerable interest in their wider potential to treat disorders involving mesenchymal (or indeed non-mesenchymal) cell derivatives, such as in Parkinson's disease.

Citing Articles

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Fibroblast growth factor 2 promotes osteo/odontogenic differentiation in stem cells from the apical papilla by inhibiting PI3K/AKT pathway.

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Cyclic stretch induced epigenetic activation of periodontal ligament cells.

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