Danazol in Non-splenectomized Patients with Refractory Idiopathic Thrombocytopenic Purpura

Overview

Journal Postgrad Med J

Publisher Oxford University Press

Specialty General Medicine

Date 1990 Oct 1

PMID 2099421

Citations 3

Authors

D.Z. Edelmann

B Knobel

I Virag

D Meytes

Affiliations

Soon will be listed here.

Abstract

Seven non-splenectomized patients with chronic refractory idiopathic thrombocytopenic purpura were treated with danazol 800 mg daily. All were glucocorticoid failures and four were refractory to all additional previous therapy. Five patients benefited from danazol and in two sustained normal platelet counts, for over 44 and 51 months, were observed. We conclude that danazol is useful for long term management of otherwise refractory idiopathic thrombocytopenic purpura. The advantage of danazol over splenectomy as a first line treatment in steroid failure is suggested.

Citing Articles

Safety and efficacy of danazol in immune thrombocytopenia: a systematic review.

Shah S, Yadav R, Bhattarai A, Dahal K, Tharu S, Gautam S Res Pract Thromb Haemost. 2024; 8(4):102444.

PMID: 38988949 PMC: 11234045. DOI: 10.1016/j.rpth.2024.102444.

Danazol in Refractory Autoimmune Hemolytic Anemia or Immune Thrombocytopenia: A Case Series Report and Literature Review.

Huang H, Lin K, Lin J, Lin Y, He H, Wang Y Pharmaceuticals (Basel). 2022; 15(11).

PMID: 36355549 PMC: 9692819. DOI: 10.3390/ph15111377.

Immunomodulatory treatments for persistent and chronic immune thrombocytopenic purpura: A PRISMA-compliant systematic review and meta-analysis of 28 studies.

Weber E, Reynaud Q, Fort R, Durupt S, Cathebras P, Durieu I Medicine (Baltimore). 2017; 96(37):e7534.

PMID: 28906353 PMC: 5604622. DOI: 10.1097/MD.0000000000007534.

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