The Generation R Study: a Candidate Gene Study and Genome-wide Association Study (GWAS) on Health-related Quality of Life (HRQOL) of Mothers and Young Children

Overview

Journal Qual Life Res

Specialties Pharmacology
Rehabilitation Medicine

Date 2010 Oct 29

PMID 20981491

Citations 9

Authors

Hein Raat

Lenie van Rossem

Vincent W V Jaddoe

Jeanne M Landgraf

David Feeny

Henriette A Moll

Albert Hofman

Johan P Mackenbach

Affiliations

Soon will be listed here.

Abstract

Aim: The aim of this paper is to describe the Generation R study as a template that enables candidate gene study and genome-wide association study regarding health-related quality of life (HRQOL) of mothers and their young children.

Methods: Generation R is a population-based prospective cohort study from fetal life onwards in Rotterdam, The Netherlands. Children were born in 2002-2006. Blood from mothers and placenta cord blood were sampled. Mothers' HRQOL was measured 5 times during pregnancy and after birth using SF-12 and EQ-5D. Children's HRQOL was measured 5 times between age 1 and 5/6 years using Infant-Toddler Quality Of Life questionnaire (ITQOL), Health Status Classification System PreSchool (HSCS-PS) and Child Health Questionnaire Parent Form 28 items (CHQ-PF28), respectively.

Results: DNA is available for 8,055 mothers and 5,908 children. Genotyping of various candidate genes and a genome-wide association (GWA) scan (Illumina 610K) of child DNA were done. A template for gene-HRQOL analyses is provided. We start with candidate gene study on HRQOL of mothers and children. Gene-environment interaction and interaction with medical indicators of health status will be explored. Next, GWA study on HRQOL will be performed.

Conclusions: Gaining insight into the determinants of HRQOL is essential to assisting efforts in health policy and clinical application to improve well-being and health. In the future, it might be possible to complement HRQOL assessments by examinations of genetic markers. Strengths and weaknesses of the Generation R study are discussed.

Citing Articles

The Generation R Study: design and cohort update 2017.

Kooijman M, Kruithof C, Van Duijn C, Duijts L, Franco O, van IJzendoorn M Eur J Epidemiol. 2017; 31(12):1243-1264.

PMID: 28070760 PMC: 5233749. DOI: 10.1007/s10654-016-0224-9.

The Generation R Study: Biobank update 2015.

Kruithof C, Kooijman M, Van Duijn C, Franco O, de Jongste J, Klaver C Eur J Epidemiol. 2014; 29(12):911-27.

PMID: 25527369 DOI: 10.1007/s10654-014-9980-6.

Conceptual and Analytical Considerations toward the Use of Patient-Reported Outcomes in Personalized Medicine.

Alemayehu D, Cappelleri J Am Health Drug Benefits. 2014; 5(5):310-7.

PMID: 24991329 PMC: 4046457.

Letter to the Editor: Concerning Paltzer, Jason, Emily Barker, and Whitney P. Witt: Measuring the health-related quality of life (HRQoL) of young children in resource-limited settings: a review of existing measures, Quality of Life Research: Vol.....

Barr R, Feeny D, Furlong W, Horsman J Qual Life Res. 2013; 23(4):1047-8.

PMID: 24132349 DOI: 10.1007/s11136-013-0558-7.

Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.

McGrath L, Cornelis M, Lee P, Robinson E, Duncan L, Barnett J Am J Med Genet B Neuropsychiatr Genet. 2013; 162B(8):779-88.

PMID: 24039173 PMC: 4019336. DOI: 10.1002/ajmg.b.32190.

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