Structure and Synthesis of 2-aminoimidazole Alkaloids from Leucetta and Clathrina Sponges

Overview

Journal Nat Prod Rep

Publisher Royal Society of Chemistry

Date 2010 Oct 29

PMID 20981389

Citations 19

Authors

Panduka B Koswatta

Carl J Lovely

Affiliations

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Abstract

Marine sponges belonging to the Calcarea family have been studied for some time and have yielded a wide variety of structurally unique secondary metabolites. In particular, these sponges have produced a large number of bioactive alkaloids containing an imidazole heterocycle, typically substituted with two benzylic fragments at various locations around the azole nucleus and at various oxidation states. This review will describe the isolation, structural determination and synthetic studies towards this growing class of natural products.

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