P2X(7) Receptor at the Heart of Disease

Overview

Journal Hippokratia

Specialty General Medicine

Date 2010 Oct 29

PMID 20981163

Citations 9

Authors

Ei Vasileiou

R M Montero

C M Turner

G Vergoulas

Affiliations

Soon will be listed here.

Abstract

Purinergic signaling is a crucial component of disease whose pathophysiological basis is now well established. This review focuses on P2X(7), a unique bifunctional purinoreceptor that either opens a non selective cation channel or forms a large, cytolytic pore depending on agonist application and leading to membrane blebbing and to cell death either by necrosis or apoptosis.Activation of P2X(7) receptor has been shown to stimulate the release of multiple proinflammatory cytokines by activated macrophages, with the IL-1b to be the most extensively studied among them. These findings were verified by the use of knockout P2X(7) ((-/-)) mice.Update information coming from all fields of research implicate this receptor at the very heart of diseases such as rheumatoid arthritis, multiple sclerosis, depression, Alzheimer disease, and to kidney damage, in renal fibrosis and experimental nephritis.Clinical studies are currently underway with the newly developed selective antagonists for P2X(7) receptor, the results of which are eagerly anticipated. These studies together with data from in-vivo experiments with the P2X(7) knockout mice and in-vitro experiments will shed light in this exciting area.

Citing Articles

Role and therapeutic targets of P2X7 receptors in neurodegenerative diseases.

Zheng H, Liu Q, Zhou S, Luo H, Zhang W Front Immunol. 2024; 15:1345625.

PMID: 38370420 PMC: 10869479. DOI: 10.3389/fimmu.2024.1345625.

Mechanism of P2X7 receptor-dependent enhancement of neuromuscular transmission in pannexin 1 knockout mice.

Miteva A, Gaydukov A, Shestopalov V, Balezina O Purinergic Signal. 2018; 14(4):459-469.

PMID: 30362043 PMC: 6298918. DOI: 10.1007/s11302-018-9630-7.

Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer's Disease.

Tandon A, Singh S, Chaturvedi R Biomed Res Int. 2018; 2018:1483791.

PMID: 30112360 PMC: 6077677. DOI: 10.1155/2018/1483791.

The effects of NONRATT021972 lncRNA siRNA on PC12 neuronal injury mediated by P2X7 receptor after exposure to oxygen-glucose deprivation.

Li G, Zou L, Xie W, Wen S, Xie Q, Gao Y Purinergic Signal. 2016; 12(3):479-87.

PMID: 27100355 PMC: 5023628. DOI: 10.1007/s11302-016-9513-8.

LncRNA NONRATT021972 involved the pathophysiologic processes mediated by P2X7 receptors in stellate ganglia after myocardial ischemic injury.

Zou L, Tu G, Xie W, Wen S, Xie Q, Liu S Purinergic Signal. 2015; 12(1):127-37.

PMID: 26630943 PMC: 4749525. DOI: 10.1007/s11302-015-9486-z.

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