Immunodeficiency Secondary to Anticytokine Autoantibodies

Overview

Journal Curr Opin Allergy Clin Immunol

Specialty Allergy & Immunology

Date 2010 Oct 23

PMID 20966748

Citations 33

Authors

Sarah K Browne

Steven M Holland

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Anticytokine autoantibodies are an important and emerging mechanism of disease pathogenesis. We will review the clinical and laboratory features of syndromes in which immunodeficiency is caused by or associated with neutralizing anticytokine autoantibodies.

Recent Findings: A growing number of patients have been described who demonstrate unique infectious phenotypes associated with neutralizing autoantibodies that target a particular cytokine known to participate in host defense against the offending organism. Examples include antigranulocyte macrophage-colony stimulating factor (GM-CSF) autoantibodies and pulmonary alveolar proteinosis; anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria (NTM); anti-interleukin-(IL)-6 autoantibodies and severe staphylococcal skin infection; anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies in patients with mucocutaneous candidiasis in the setting of both the autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy (APECED) syndrome and in cases of thymoma.

Summary: Anticytokine autoantibodies have manifestations that are diverse, ranging from asymptomatic to life-threatening. These emerging and fascinating causes of acquired immunodeficiency may explain some previously idiopathic syndromes.

Citing Articles

Utility of atherosclerosis-associated serum antibodies against colony-stimulating factor 2 in predicting the onset of acute ischemic stroke and prognosis of colorectal cancer.

Li S, Yoshida Y, Kubota M, Zhang B, Matsutani T, Ito M Front Cardiovasc Med. 2023; 10:1042272.

PMID: 36844744 PMC: 9954151. DOI: 10.3389/fcvm.2023.1042272.

Opportunistic Infection Associated With Elevated GM-CSF Autoantibodies: A Case Series and Review of the Literature.

Lee E, Miller C, Ataya A, Wang T Open Forum Infect Dis. 2022; 9(5):ofac146.

PMID: 35531378 PMC: 9070348. DOI: 10.1093/ofid/ofac146.

Human autoantibodies underlying infectious diseases.

Puel A, Bastard P, Bustamante J, Casanova J J Exp Med. 2022; 219(4).

PMID: 35319722 PMC: 8952682. DOI: 10.1084/jem.20211387.

The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review.

Ataya A, Knight V, Carey B, Lee E, Tarling E, Wang T Front Immunol. 2021; 12:752856.

PMID: 34880857 PMC: 8647160. DOI: 10.3389/fimmu.2021.752856.

Cryptococcus gattii Species Complex as an Opportunistic Pathogen: Underlying Medical Conditions Associated with the Infection.

Yang D, England M, Salvator H, Anjum S, Park Y, Marr K mBio. 2021; 12(5):e0270821.

PMID: 34700378 PMC: 8546560. DOI: 10.1128/mBio.02708-21.

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