Structures of 2-acetylaminofluorene Modified DNA Revisited: Insight into Conformational Heterogeneity

Overview

Journal Chem Res Toxicol

Publisher American Chemical Society

Specialty Toxicology

Date 2010 Oct 20

PMID 20954689

Citations 16

Authors

Satyakam Patnaik

Bongsup P Cho

Affiliations

Soon will be listed here.

Abstract

Despite the extensive data on dG-AAF, the major DNA adduct derived from the model carcinogen 2-acetylaminofluorene, little is known with respect to its solution structures. Here, we provide NMR/CD evidence for three conformers of dG-AAF in duplex DNA: major groove B-type (B), base-displaced stacked (S), and minor groove wedge (W). The S/B/W-conformational heterogeneities were found to be sensitive to the nature of the flanking DNA sequence contexts and pH.

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