Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2010 Oct 19

PMID 20953376

Citations 1

Authors

Andrea Stofkova

Blanka Zelezna

Marianna Romzova

Olga Ulicna

Alexander Kiss

Martina Skurlova

Jana Jurcovicova

Affiliations

Soon will be listed here.

Abstract

We studied the effect of food restriction, overfeeding, and normofeeding on cachexia, inflammatory and metabolic parameters, and insulin sensitivity in chronic adjuvant arthritis (AA) in rats. Food restriction during AA increased circulating ghrelin, corticosterone, decreased leptin, and ameliorated arthrogram score and systemic inflammation compared to normofeeding. Overfeeding worsened arthrogram score and systemic inflammation, and led to lipid accumulation in the liver, but not to alterations of adipokine and ghrelin plasma levels relative to normofeeding. Independently of feeding status, AA induced cachexia, in which modulation of mRNA expressions for appetite-regulating neuropeptides (NPY, AgRP, POMC, CART) in the arcuate nucleus (ARC) does not play a primary role. The overexpression of IL-1β mRNA in the ARC suggests its role in the mechanisms of impaired energy balance during AA under all feeding conditions. Normal HOMA index in all arthritic groups does not indicate the development of insulin resistance by feeding interventions in these rats.

Citing Articles

Appetite Regulation of TLR4-Induced Inflammatory Signaling.

Li Y, Jiang Q, Wang L Front Endocrinol (Lausanne). 2021; 12:777997.

PMID: 34899611 PMC: 8664591. DOI: 10.3389/fendo.2021.777997.

References

Stofkova A . Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity. Endocr Regul. 2009; 43(4):157-68. View

Gonzalez-Rey E, Chorny A, Delgado M . Therapeutic action of ghrelin in a mouse model of colitis. Gastroenterology. 2006; 130(6):1707-20. DOI: 10.1053/j.gastro.2006.01.041. View

Theil M, Miyake S, Mizuno M, Tomi C, Croxford J, Hosoda H . Suppression of experimental autoimmune encephalomyelitis by ghrelin. J Immunol. 2009; 183(4):2859-66. DOI: 10.4049/jimmunol.0803362. View

Leclercq I, da Silva Morais A, Schroyen B, Van Hul N, Geerts A . Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences. J Hepatol. 2007; 47(1):142-56. DOI: 10.1016/j.jhep.2007.04.002. View

Ogimoto K, Harris Jr M, Wisse B . MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta. Endocrinology. 2006; 147(9):4445-53. DOI: 10.1210/en.2006-0465. View

Stofkova A, Skurlova M, Tybitanclova K, Veselsky L, Zelezna B, Jurcovicova J . Relationship among nitric oxide, leptin, ACTH, corticosterone, and IL-1beta, in the early and late phases of adjuvant arthritis in male Long Evans rats. Life Sci. 2006; 79(26):2486-91. DOI: 10.1016/j.lfs.2006.08.015. View

Bays H, Gonzalez-Campoy J, Bray G, Kitabchi A, Bergman D, Schorr A . Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity. Expert Rev Cardiovasc Ther. 2008; 6(3):343-68. DOI: 10.1586/14779072.6.3.343. View

Kent S, Rodriguez F, Kelley K, Dantzer R . Reduction in food and water intake induced by microinjection of interleukin-1 beta in the ventromedial hypothalamus of the rat. Physiol Behav. 1994; 56(5):1031-6. DOI: 10.1016/0031-9384(94)90339-5. View

Bruun J, Lihn A, Verdich C, Pedersen S, Toubro S, Astrup A . Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab. 2003; 285(3):E527-33. DOI: 10.1152/ajpendo.00110.2003. View

10.

Plata-Salaman C, Ilyin S, Gayle D . Brain cytokine mRNAs in anorectic rats bearing prostate adenocarcinoma tumor cells. Am J Physiol. 1998; 275(2):R566-73. DOI: 10.1152/ajpregu.1998.275.2.R566. View

11.

Lennie T, McCarthy D, KEESEY R . Body energy status and the metabolic response to acute inflammation. Am J Physiol. 1995; 269(5 Pt 2):R1024-31. DOI: 10.1152/ajpregu.1995.269.5.R1024. View

12.

Granado M, Priego T, Martin A, Villanua M, Lopez-Calderon A . Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. Am J Physiol Endocrinol Metab. 2004; 288(3):E486-92. DOI: 10.1152/ajpendo.00196.2004. View

13.

Martin A, Castillero E, Granado M, Lopez-Menduina M, Villanua M, Lopez-Calderon A . Adipose tissue loss in adjuvant arthritis is associated with a decrease in lipogenesis, but not with an increase in lipolysis. J Endocrinol. 2008; 197(1):111-9. DOI: 10.1677/JOE-07-0491. View

14.

Busso N, So A, Chobaz-Peclat V, Morard C, Martinez-Soria E, Talabot-Ayer D . Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol. 2002; 168(2):875-82. DOI: 10.4049/jimmunol.168.2.875. View

15.

Stofkova A . Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity. Endocr Regul. 2010; 44(1):25-36. DOI: 10.4149/endo_2010_01_25. View

16.

Otero M, Nogueiras R, Lago F, Dieguez C, Gomez-Reino J, Gualillo O . Chronic inflammation modulates ghrelin levels in humans and rats. Rheumatology (Oxford). 2003; 43(3):306-10. DOI: 10.1093/rheumatology/keh055. View

17.

Dahl T, Yndestad A, Skjelland M, Oie E, Dahl A, Michelsen A . Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization. Circulation. 2007; 115(8):972-80. DOI: 10.1161/CIRCULATIONAHA.106.665893. View

18.

Korner J, Savontaus E, Chua Jr S, Leibel R, Wardlaw S . Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus. J Neuroendocrinol. 2001; 13(11):959-66. DOI: 10.1046/j.1365-2826.2001.00716.x. View

19.

Lennie T . Relationship of body energy status to inflammation-induced anorexia and weight loss. Physiol Behav. 1998; 64(4):475-81. DOI: 10.1016/s0031-9384(98)00103-6. View

20.

Reyes T, Sawchenko P . Involvement of the arcuate nucleus of the hypothalamus in interleukin-1-induced anorexia. J Neurosci. 2002; 22(12):5091-9. PMC: 6757734. View