Therapeutic Options for Lymphangioleiomyomatosis (LAM): Where We Are and Where We Are Going

Overview

Journal F1000 Med Rep

Specialty General Medicine

Date 2010 Oct 16

PMID 20948684

Citations 5

Authors

Angelo M Taveira-DaSilva

Wendy K Steagall

Joel Moss

Affiliations

Soon will be listed here.

Abstract

Lymphangioleiomyomatosis (LAM), a multisystem disease affecting predominantly premenopausal and middle-aged women, causes progressive respiratory failure due to cystic lung destruction and is associated with lymphatic and kidney tumors. In the past, the treatment of LAM comprised exclusively anti-estrogen and related hormonal therapies. These treatments, however, have not been proven effective. In this article, we discuss new findings regarding the molecular mechanisms involved in the regulation of LAM cell growth, which may offer opportunities to develop effective and targeted therapeutic agents.

Citing Articles

Effects of Sirolimus on Lung function in patients with Lymphangioleiomyomatosis.

Aghaeimeybodi F, Najafizadeh K, Razavi-Ratki S, Namiranian N Caspian J Intern Med. 2019; 10(1):7-10.

PMID: 30858935 PMC: 6386328. DOI: 10.22088/cjim.10.1.7.

Familial syndromes associated with intracranial tumours: a review.

Ranger A, Patel Y, Chaudhary N, Anantha R Childs Nerv Syst. 2013; 30(1):47-64.

PMID: 24193148 DOI: 10.1007/s00381-013-2309-z.

Lymphangioleiomyomatosis: current and future.

Mavroudi M, Zarogoulidis P, Katsikogiannis N, Tsakiridis K, Huang H, Sakkas A J Thorac Dis. 2013; 5(1):74-9.

PMID: 23372952 PMC: 3548000. DOI: 10.3978/j.issn.2072-1439.2013.01.03.

Progress in the treatment of lymphangioleiomyomatosis: from bench to bedside.

Taveira-DaSilva A, Moss J Rev Port Pneumol. 2012; 18(3):142-4.

PMID: 22480994 PMC: 4142050. DOI: 10.1016/j.rppneu.2012.02.005.

[A clinicopathological analysis of pulmonary lymphangioleiomyomatosis].

Gao J, Zhu P, Zhang S, Zhao S, Lu C, Chen H Zhongguo Fei Ai Za Zhi. 2011; 14(4):378-82.

PMID: 21496440 PMC: 5999720. DOI: 10.3779/j.issn.1009-3419.2011.04.14.

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