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Diagnostic Value of Adenosine Deaminase in Cerebrospinal Fluid for Tuberculous Meningitis: a Meta-analysis

Overview
Journal Int J Tuberc Lung Dis
Specialty Pulmonary Medicine
Date 2010 Oct 13
PMID 20937176
Citations 23
Authors
H-B Xu
R-H Jiang
L Li
W Sha
H-P Xiao
Affiliations
Soon will be listed here.
Abstract

Objective: To determine the accuracy of adenosine deaminase (ADA) measurements in the diagnosis of tuberculous meningitis (TBM).

Design: After a systematic review of English language studies, the sensitivity, specificity and accuracy of ADA concentrations in the diagnosis of cerebrospinal fluid (CSF) were evaluated using random effects models. Summary receiver operating characteristic curves were used to summarise overall test performance.

Results: Ten studies met our inclusion criteria. The sensitivity of ADA in the diagnosis of TBM was 0.79 (95%CI 0.75-0.83), specificity 0.91 (95%CI 0.89-0.93), positive likelihood ratio 6.85 (95%CI 4.11-11.41), negative likelihood ratio 0.29 (95%CI 0.19-0.44) and diagnostic odds ratio 26.93 (95%CI 12.73-56.97).

Conclusion: Our data suggest that ADA in the CSF can be a sensitive and specific target and a critical criteria for the diagnosis of TBM.

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