Post-translational Modifications of Microtubules

Overview

Journal J Cell Sci

Specialty Cell Biology

Date 2010 Oct 9

PMID 20930140

Citations 125

Authors

Dorota Wloga

Jacek Gaertig

Affiliations

Soon will be listed here.

Abstract

Microtubules--polymers of tubulin--perform essential functions, including regulation of cell shape, intracellular transport and cell motility. How microtubules are adapted to perform multiple diverse functions is not well understood. Post-translational modifications of tubulin subunits diversify the outer and luminal surfaces of microtubules and provide a potential mechanism for their functional specialization. Recent identification of a number of tubulin-modifying and -demodifying enzymes has revealed key roles of tubulin modifications in the regulation of motors and factors that affect the organization and dynamics of microtubules.

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