Mycobacterium Africanum--review of an Important Cause of Human Tuberculosis in West Africa

Overview

Journal PLoS Negl Trop Dis

Specialties Infectious Diseases
Tropical Medicine

Date 2010 Oct 8

PMID 20927191

Citations 134

Authors

Bouke C de Jong

Martin Antonio

Sebastien Gagneux

Affiliations

Soon will be listed here.

Abstract

Mycobacterium africanum consists of two phylogenetically distinct lineages within the Mycobacterium tuberculosis complex, known as M. africanum West African 1 and M. africanum West African 2. These lineages are restricted to West Africa, where they cause up to half of human pulmonary tuberculosis. In this review we discuss the definition of M. africanum, describe the prevalence and restricted geographical distribution of M. africanum West African 1 and 2, review the occurrence of M. africanum in animals, and summarize the phenotypic differences described thus far between M. africanum and M. tuberculosis sensu stricto.

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