Congenital Lipodystrophy: An Endocrine Study in Three Siblings. I. Disorders of Carbohydrate Metabolism

Overview

Journal J Pediatr

Specialty Pediatrics

Date 1978 Aug 1

PMID 209163

Citations 4

Authors

C Huseman

A Johanson

M Varma

R M BLIZZARD

Affiliations

Soon will be listed here.

Abstract

Three siblings with congenital lipodystrophy were studied extensively for endocrine abnormalities. A severe disturbance in carbohydrate metabolism was observed. Plasma concentrations of glucagon and insulin were markedly elevated both in the basal state and in response to provocative stimuli. In addition, marked resistance to exogenous insulin and a diabetic oral glucose tolerance test were demonstrated. Lipid metabolism, GH, and ACTH secretion were normal...

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