Cyclic Phosphates of Formycin

Overview

Journal J Antibiot (Tokyo)

Specialties Infectious Diseases
Pharmacology

Date 1978 May 1

PMID 209007

Citations 2

Authors

O Makabe

A Miyadera

M Kinoshita

S Umezawa

Affiliations

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Abstract

The syntheses of N1- and N2-isopropylformycin (10, 11), formycin 3',5'-cyclic and 2',3'-cyclic phosphate (3,7) and their N-methyl and N-isopropyl derivatives (13, 15, 19, 23) are described. It was observed that substitution at N1 or N2 with a bulky alkyl group or cyclic phosphorylation of the ribose moiety made formycin resistant to adenosine deaminase.

Citing Articles

Formycin 5'-triphosphate, a fluorescent analog of ATP, as a substrate for adenylate cyclase.

Rossomando E, Jahngen J, Eccleston J Proc Natl Acad Sci U S A. 1981; 78(4):2278-82.

PMID: 6941284 PMC: 319328. DOI: 10.1073/pnas.78.4.2278.

Synthesis of 5-chloroformycin A, 5-chloro-2'-deoxyformycin A and certain related 5,7-disubstituted 3-beta-D-ribofuranosylpyrazolo[4,3-d] pyrimidines from formycin A.

Upadhya K, Sanghvi Y, ROBINS R, Revankar G, Ugarkar B Nucleic Acids Res. 1986; 14(4):1747-64.

PMID: 3951995 PMC: 339570. DOI: 10.1093/nar/14.4.1747.