Dissociations Within Human Hippocampal Subregions During Encoding and Retrieval of Spatial Information

Overview

Journal Hippocampus

Publisher Wiley

Date 2010 Oct 1

PMID 20882543

Citations 33

Authors

Nanthia Suthana

Arne Ekstrom

Saba Moshirvaziri

Barbara Knowlton

Susan Bookheimer

Affiliations

Soon will be listed here.

Abstract

Although the hippocampus is critical for the formation and retrieval of spatial memories, it is unclear how subregions are differentially involved in these processes. Previous high-resolution functional magnetic resonance imaging (fMRI) studies have shown that CA2, CA3, and dentate gyrus (CA23DG) regions support the encoding of novel associations, whereas the subicular cortices support the retrieval of these learned associations. Whether these subregions are used in humans during encoding and retrieval of spatial information has yet to be explored. Using high-resolution fMRI (1.6 mm × 1.6-mm in-plane), we found that activity within the right CA23DG increased during encoding compared to retrieval. Conversely, right subicular activity increased during retrieval compared to encoding of spatial associations. These results are consistent with the previous studies illustrating dissociations within human hippocampal subregions and further suggest that these regions are similarly involved during the encoding and retrieval of spatial information.

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